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Poloxamer 407

CAS 691397-13-4

Concern score

Not assessed — no hazard data yet.

Poloxamer 407 in plain language

What it is

Also known as Pluracare f 127 · Pluronic F-127

What it does

We don't have a plain-language description for Poloxamer 407 yet.

Is it a concern?
We haven't assessed a concern score for this ingredient yet.

Regulation

No restrictions found. Poloxamer 407 appears in these published regulatory listings.

  • Inactive ingredient in US drugs
  • USFDAinactive ingredient database15 entries — 5 administration routes
    • Route: INTRATYMPANIC; Dosage form: SUSPENSION; Maximum daily exposure: 63 mgSource →
    • Route: OPHTHALMIC; Dosage form: GEL; Maximum daily exposure: 1 mgSource →
    • Route: OPHTHALMIC; Dosage form: SOLUTION; Potency: 0.2 %w/vSource →
    • Route: OPHTHALMIC; Dosage form: SUSPENSION/ DROPS; Maximum daily exposure: 1 mgSource →
    • Route: ORAL; Dosage form: CAPSULE; Maximum daily exposure: 468 mgSource →
    • Route: ORAL; Dosage form: CAPSULE, DELAYED RELEASE; Maximum daily exposure: 5 mgSource →
    • Route: ORAL; Dosage form: CAPSULE, EXTENDED RELEASE; Maximum daily exposure: 40 mgSource →
    • Route: ORAL; Dosage form: POWDER, FOR SUSPENSION; Potency: 0.01 mgSource →
    • Route: ORAL; Dosage form: SOLUTION; Potency: 50 mg/5mlSource →
    • Route: ORAL; Dosage form: SUSPENSION; Maximum daily exposure: 10 mgSource →
    • Route: ORAL; Dosage form: TABLET; Maximum daily exposure: 495 mgSource →
    • Route: PERIODONTAL; Dosage form: GEL; Potency: 155 mgSource →
    • Route: TOPICAL; Dosage form: CREAM; Maximum daily exposure: 13 mgSource →
    • Route: TOPICAL; Dosage form: GEL; Maximum daily exposure: 28 mgSource →
    • Route: TOPICAL; Dosage form: LOTION; Potency: 1 %w/wSource →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as polymer.
    • openFDA substance registry classifies this ingredient as polymer.Source →

Evidence & sources

No graded research studies for Poloxamer 407 yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

3 data sources

Where this comes from

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →
Reference links (1)
Openfda substance

sanrisechem.com

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Catalog

Found in these products

Their ingredient lists include Poloxamer 407; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 193 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Poloxamer 407 in the catalog.