What does Lysine hydrochloride do?

Used in consumer products as a flavouring and a conditioner.

Is Lysine hydrochloride safe?

Moderate concern: no hazard classifications on record.

beauty
cleaning
food
industrial

Lysine hydrochloride

CAS 657-27-2 · 40/100 · High conf.

Also registered as 4 other CAS numbers

10098-89-2 · 28826-16-6 · 305-76-0 · 93394-22-0

Concern score

40/100Moderate concern based on regulatory listings.

High confidence

Lysine hydrochloride in plain language

What it is: Also known as L-lysine hydrochloride · L-lysine monohydrochloride · Lysine monohydrochloride · L-(+)-Lysine monohydrochloride · Lysine hcl · (2S)-2,6-diaminohexanoic acid;hydrochloride
Show all 23 names
L-Lysine--hydrogen chloride (1/1) · Lysine hcl, l- · Lysine, l-, monohydrochloride · (2S)-2,6-Diaminohexanoic acid monohydrochloride · (S)-2,6-DIAMINOHEXANOIC acid monohydrochloride · (S)-2,6-Diaminohexanoic acid hydrochloride · Enisyl-f · H-Lys-OH.HCl · L-Lysine HCl · L-Lysine monohydrocholoride · L-Lysine, hydrochloride (1:1) · Lyamine · Trulysine · Viralys · l-Lysine monochlorhydrate · l-lysine monohydrochloride calibration marker · clorhidrato lisina
What it does: Used in consumer products as a flavouring and a conditioner.
Flavouring
Conditioner
Is it a concern?: Moderate concern: no hazard classifications on record.

Why it's flagged

EPA CPDat observed this chemical in 184 composition records across product categories including Laboratory supplies, Personal care, Food and drug.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Lysine hydrochloride appears in these published regulatory listings.

In marketed US drugs
Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Pharma
Food
Industrial

EUEFSAEFSA opinion6 entries
- Magnesium L-lysinate, calcium L- lysinate, zinc L- lysinate as sources for magnesium, calcium and zinc added for nutritional purposes in food supplements - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)Source →
- Scientific Opinion on the safety and efficacy of concentrated liquid L-lysine (base), concentrated liquid L-lysine monohydrochloride and L-lysine monohydrochloride technically pure produced using Escherichia coli (FERM BP-11355) for all animal species based on a dossier submitted by Ajinomoto Eurolysine S.A.S (EFSA FEEDAP)Source →
- Scientific opinion on the safety and efficacy of concentrated liquid L-lysine (base), concentrated liquid L-lysine monohydrochloride and L-lysine monohydrochloride produced by Escherichia coli (FERM BP-10941) for all animal species, based on three dossiers submitted by Ajinomoto Eurolysine SAS (EFSA FEEDAP)Source →
- Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 26: Amino acids from chemical group 34(Commission Regulation (EC) No 1565/2000 of 18 July 2000) (EFSA AFC)Source →
- Amino acids from chemical group 34. Flavouring Group Evaluation 26, Revision 1. Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) (EFSA AFC)Source →
- Safety of L-lysine monohydrochloride produced by fermentation with Escherichia coli CGMCC 7.57 for all animal species based on a dossier submitted by Feedway Europe NV (EFSA FEEDAP)Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 184 composition records across product categories including Laboratory supplies, Personal care, Food and drug. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Flavouring and nutrient, Fatty Acid.
- EPA CPDat observed this chemical in 184 composition records across product categories including Laboratory supplies, Personal care, Food and drug. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Flavouring and nutrient, Fatty Acid.Source →
USFDAinactive ingredient databaseRoute: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 5040 mg
- Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 5040 mgSource →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 3 active drug products and 3 total products.
- FDA NDC lists this ingredient in 3 active drug products and 3 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
JECFA
Joint FAO/WHO Expert Committee on Food Additives
No JECFA evaluation on file.
EFSA
European Food Safety Authority
- Magnesium L-lysinate, calcium L- lysinate, zinc L- lysinate as sources for magnesium, calcium and zinc added for nutritional purposes in food supplements - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)
  2008 · EU EFSA listing · Read the source →
- Scientific Opinion on the safety and efficacy of concentrated liquid L-lysine (base), concentrated liquid L-lysine monohydrochloride and L-lysine monohydrochloride technically pure produced using Escherichia coli (FERM BP-11355) for all animal species based on a dossier submitted by Ajinomoto Eurolysine S.A.S (EFSA FEEDAP)
  2014 · EU EFSA listing · Read the source →
- Scientific opinion on the safety and efficacy of concentrated liquid L-lysine (base), concentrated liquid L-lysine monohydrochloride and L-lysine monohydrochloride produced by Escherichia coli (FERM BP-10941) for all animal species, based on three dossiers submitted by Ajinomoto Eurolysine SAS (EFSA FEEDAP)
  2013 · EU EFSA listing · Read the source →
- Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 26: Amino acids from chemical group 34(Commission Regulation (EC) No 1565/2000 of 18 July 2000) (EFSA AFC)
  2010 · EU EFSA listing · Read the source →
- Amino acids from chemical group 34. Flavouring Group Evaluation 26, Revision 1. Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) (EFSA AFC)
  2008 · EU EFSA listing · Read the source →
- Safety of L-lysine monohydrochloride produced by fermentation with Escherichia coli CGMCC 7.57 for all animal species based on a dossier submitted by Feedway Europe NV (EFSA FEEDAP)
  2016 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Lysine hydrochloride yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated September 2013
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA National Drug Code Directory
regulatory · updated 2026-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Lysine hydrochloride in a product composition. These are source records, not Greenveil catalog products.

Source records

184

Named organisations

Laboratory suppliesPersonal careFood and drug

Typical roles

FlavouringConditioner

See products using Lysine hydrochloride →

Catalog

Found in these products

Their ingredient lists include Lysine hydrochloride; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 87 →Find products without it →