Citicoline

CAS 987-78-0 · 20/100 · High conf.

Also registered as 3 other CAS numbers

1477-47-0 · 64143-42-6 · 769081-33-6

Concern score

20/100Minor concern based on regulatory listings.

High confidence

Citicoline in plain language

What it is: Also known as Cdp-choline · Cytidine 5'-DIPHOSPHATE choline · CDP-cholin · CDP-colina · Choline 5'-cytidine diphosphate · Choline cytidine diphosphate
Show all 21 names
Citicholine · Citicolin · Citicolinum · Cytidindiphosphocholin · Cytidine 5'-(choline diphosphate) · Cytidine 5'-(cholinyl pyrophosphate) · Cytidine 5'-diphosphoric choline · Cytidine 5-diphosphocholine · Ip 302 · Nicholin · cidifos · citicolina · citidin difosfato de colina · cytidine 5'-diphosphocholine · cytidine diphosphate choline
What it does: We don't have a plain-language description for Citicoline yet.
Is it a concern?: Minor concern: no hazard classifications on record.

Why it's flagged

EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Citicoline appears in these published regulatory listings.

In marketed US drugs

Recorded in these product areas

Found in consumer products
Industrial

EUEFSAEFSA opinionScientific Opinion on the safety of 'citicoline' as a Novel Food ingredient (EFSA NDA)
- Scientific Opinion on the safety of 'citicoline' as a Novel Food ingredient (EFSA NDA)Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.
- EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 1 active drug products and 1 total products.
- FDA NDC lists this ingredient in 1 active drug products and 1 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

JECFA
Joint FAO/WHO Expert Committee on Food Additives
No JECFA evaluation on file.
EFSA
European Food Safety Authority
- Scientific Opinion on the safety of 'citicoline' as a Novel Food ingredient (EFSA NDA)
  2013 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Citicoline yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated 2020-08-31
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA National Drug Code Directory
regulatory · updated 2026-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (1)

Openfda substance

en.wikipedia.org

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Citicoline in a product composition. These are source records, not Greenveil catalog products.

Source records

See products using Citicoline →

Catalog

Found in these products

Their ingredient lists include Citicoline; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 16 →Find products without it →