Fluoride

CAS 16984-48-8 · 100/100 · High conf.

Also registered as 1 other CAS number

405267-45-0

Concern score

100/100Critical concern based on regulatory listings.

High confidence

Fluoride in plain language

What it is: Also known as Fluoride ion · Fluoride ION(1-) · Fluorine ion · Fluorine ION(F1-) · Fluroride-ion · Perfluoride
Show all 25 names
fluoride treated Drinking water · F- · Fluoride ion (F-) · Fluoride(1-) · Fluorine ion(1-) · ion Fluorine · Fluorine- · Hydrofluoric acid, ion(1-) · Topex Neutral pH Fluoride Gel · Topex Neutral pH Fluoride GelMint · Topex Neutral pH Fluoride GelStrawberry · UNII-Q80VPU408O · complex fluorides · flouride · fluoride (total fluoride as f) · fluoride ion (1-) · fluorides · sodium fluoride or complex fluorides · fluorides (as f)
What it does: We don't have a plain-language description for Fluoride yet.
Is it a concern?: Critical concern: no hazard classifications on record.

Why it's flagged

EPA CPDat observed this chemical in 126 composition records across product categories including Medical/dental, Construction, Laboratory supplies.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Fluoride appears in these published regulatory listings.

In marketed US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Industrial

EUEFSAEFSA opinion6 entries
- Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Fluorine as undesirable substance in animal feed (EFSA CONTAM)Source →
- Sodium monofluorophosphate as a source of fluoride added for nutritional purposes to food supplements (EFSA ANS)Source →
- Opinion of the Scientific Panel on Contaminants in the Food Chain on a request of the Commission related to concentration limits for boron and fluoride in natural mineral waters (EFSA CONTAM)Source →
- Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission related to the Tolerable Upper Intake Level of Fluoride (EFSA NDA)Source →
- Scientific Opinion on Dietary Reference Values for fluoride (EFSA NDA)Source →
- Calcium fluoride as a source of fluoride added for nutritional purposes to food supplements (EFSA ANS)Source →
EUEFSAEFSA statementStatement of EFSA on the possible risks for public and animal health from the contamination of the feed and food chain due to possible ash-fall following the eruption of the Eyjafjallajökull volcano in Iceland - urgent advice (EFSA CONTAM)
- Statement of EFSA on the possible risks for public and animal health from the contamination of the feed and food chain due to possible ash-fall following the eruption of the Eyjafjallajökull volcano in Iceland - urgent advice (EFSA CONTAM)Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 126 composition records across product categories including Medical/dental, Construction, Laboratory supplies.
- EPA CPDat observed this chemical in 126 composition records across product categories including Medical/dental, Construction, Laboratory supplies.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 4 active drug products and 5 total products.
- FDA NDC lists this ingredient in 4 active drug products and 5 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
JECFA
Joint FAO/WHO Expert Committee on Food Additives
No JECFA evaluation on file.
EFSA
European Food Safety Authority
- Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Fluorine as undesirable substance in animal feed (EFSA CONTAM)
  2004 · EU EFSA listing · Read the source →
- Sodium monofluorophosphate as a source of fluoride added for nutritional purposes to food supplements (EFSA ANS)
  2008 · EU EFSA listing · Read the source →
- Opinion of the Scientific Panel on Contaminants in the Food Chain on a request of the Commission related to concentration limits for boron and fluoride in natural mineral waters (EFSA CONTAM)
  2005 · EU EFSA listing · Read the source →
- Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission related to the Tolerable Upper Intake Level of Fluoride (EFSA NDA)
  2005 · EU EFSA listing · Read the source →
- Scientific Opinion on Dietary Reference Values for fluoride (EFSA NDA)
  2013 · EU EFSA listing · Read the source →
- Statement of EFSA on the possible risks for public and animal health from the contamination of the feed and food chain due to possible ash-fall following the eruption of the Eyjafjallajökull volcano in Iceland - urgent advice (EFSA CONTAM)
  2010 · EU EFSA listing · Read the source →
- Calcium fluoride as a source of fluoride added for nutritional purposes to food supplements (EFSA ANS)
  2008 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Fluoride yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated August 2017
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Fluoride in a product composition. These are source records, not Greenveil catalog products.

Source records

126

Named organisations

Medical/dentalConstructionLaboratory suppliesRoad vehiclesRaw materialsIndustrial products

See products using Fluoride →

Catalog

Found in these products

Their ingredient lists include Fluoride; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 49 →Find products without it →