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Riboflavin

CAS 83-88-5 · 25/100 · High conf.

Also registered as 4 other CAS numbers

130609-39-1 · 535950-32-4 · 890044-91-4 · 1093390-18-1

Colorant · Dye · Flavouring and nutrient

Riboflavin chemical structure

Concern score

25/100Minor concern based on regulatory listings.
High confidence

What the listings say

Permitted, with conditions — Riboflavin appears on published "allowed" regulatory lists rather than on a restriction list.

Riboflavin is listed in Annex IV of the EU Cosmetics Regulation (EC) 1223/2009 (colorants allowed in cosmetic products).

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Riboflavin appears in these published regulatory listings.

  • In marketed US drugs
  • EU Annex IV — permitted colorant
  • EU permitted colorant
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • Industrial
  • EUECallowed_listedAnnex IV of EU Cosmetics Regulation (EC) 1223/2009: colorants allowed in cosmetic products. Conditions of use and warnings: Purity criteria as set out in Commission Directive 95/45/EC (E101)
    • Annex IV of EU Cosmetics Regulation (EC) 1223/2009: colorants allowed in cosmetic products. Conditions of use and warnings: Purity criteria as set out in Commission Directive 95/45/EC (E101)Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 127 composition records across product categories including Food and drug, Personal care, Raw materials. EPA CPDat classifies this chemical for functional uses including Dye, Softener and conditioner, Flavouring and nutrient.
    • EPA CPDat observed this chemical in 127 composition records across product categories including Food and drug, Personal care, Raw materials. EPA CPDat classifies this chemical for functional uses including Dye, Softener and conditioner, Flavouring and nutrient.Source →
  • USFDAinactive ingredient databaseRoute: ORAL; Dosage form: TABLET; Potency: 0.03 mg
    • Route: ORAL; Dosage form: TABLET; Potency: 0.03 mgSource →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 113 active drug products and 132 total products.
    • FDA NDC lists this ingredient in 113 active drug products and 132 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Evidence & sources

No graded research studies for Riboflavin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2020-08-14

    Open →
  • EPA Chemical and Products Database

    exposure · updated September 2018

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →
  • FDA National Drug Code Directory

    regulatory · updated 2029-05-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (3)
Openfda substance

en.wikipedia.org

Openfda substance

drugoffice.gov.hk

Openfda substance

codexalimentarius.net

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Riboflavin in a product composition. These are source records, not Greenveil catalog products.

Source records

132

Typical roles

ColorantDyeFlavouring and nutrientPharmaceuticalSoftener and conditioner
See products using Riboflavin

Catalog

Found in these products