- beauty
- industrial
Estradiol
CAS 50-28-2 · 100/100 · High conf.
Also registered as 4 other CAS numbers
17916-67-5 · 873662-39-6 · 1050677-52-5 · 1206475-11-7
Softener and conditioner
Concern score
100/100Critical concern based on regulatory listings.
High confidence
Why it's flagged
Oestrogens is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.
RestrictedEU EC — banned
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Regulation
Restrictions first, then routine listings from published regulatory sources.
- EU Annex II — prohibited
- EU prohibited in cosmetics
- Found in consumer products
- Beauty
- Industrial
- View source →banned
EUEC
Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.
USEPAcommercial use observedEPA CPDat observed this chemical in 7 composition records across product categories including Laboratory supplies, Personal care, Raw materials. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.
- EPA CPDat observed this chemical in 7 composition records across product categories including Laboratory supplies, Personal care, Raw materials. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Evidence & sources
No graded research studies for Estradiol yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2010-10-15
- Open →
EPA Chemical and Products Database
exposure · updated March 8, 2019
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.
Where it has been recorded
How often EPA CPDat has listed Estradiol in a product composition. These are source records, not Greenveil catalog products.
Source records
7
Named organisations
6
Laboratory suppliesPersonal careRaw materials
Typical roles
Softener and conditioner
