beauty
cleaning
food
industrial

Caffeine

CAS 114303-55-8 · 40/100 · High conf.

Also registered as 3 other CAS numbers

71701-02-5 · 95789-13-2 · 58-08-2

Concern score

40/100Moderate concern based on regulatory listings.

High confidence

Caffeine in plain language

What it is: Also known as Anhydrous caffeine · Caffeine anhydrous · 1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione · 1,3,7-trimethylpurine-2,6-dione · Caffeine melting point standard · Durvitan
Show all 56 names
Guaranine · Synalgos · Theine · Vivarin · 1,3,7-TRIMETHYL-2,6-DIOXOPURINE · 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl- · 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione · 7-Methyltheophylline · Alert-Pep · Cafamil · Cafecon · Cafeine · Caffedrine · Caffein · Cafipel · Coffeine · Koffein · Methyltheobromine · Mateina · No-Doz · Refresh'n · Stim · Thein · cafeina · caffeine (0.0001 to 0.01% concentration) · caffine · Anoquan component caffeine · Cafergot component caffeine · Caffeinum · Darvon compound component caffeine · Dhc plus component caffeine · Esgic component caffeine · Excedrin component caffeine · Femcet component caffeine · Fioricet component caffeine · Fiorinal component caffeine · Invagesic component caffeine · Invagesic forte component caffeine · Lanorinal component caffeine · Medigesic plus component caffeine · Migergot component caffeine · Norgesic component caffeine · Orphengesic component caffeine · Orphengesic forte component caffeine · Synalgos-dc component caffeine · Synalgos-dc-a component caffeine · Triad component caffeine · Wigraine component caffeine · Trezix component caffeine · coffeinum
What it does: Used in cosmetics as a skin-conditioning agent and a fragrance ingredient. Caffeine is the heterocyclic organic compound.
Skin conditioning
Perfuming
Fragrance
Flavouring
Conditioner
Deodorant
Is it a concern?: Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 921 composition records across product categories including Laboratory supplies, Personal care, Raw materials.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Caffeine appears in these published regulatory listings.

In marketed US drugs
Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Pharma
Food
Industrial

EUEFSAEFSA opinion3 entries
- Flavouring Group Evaluation 49, (FGE.49)1: Xanthin alkaloids from the Priority list from chemical group 30 Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)Source →
- Scientific Opinion on Flavouring Group Evaluation 49, Revision 1 (FGE.49Rev1): xanthine alkaloids from the priority list (EFSA CEF)Source →
- Scientific Opinion on the safety of caffeine (EFSA NDA)Source →
USFDAinactive ingredient database3 entries — 3 administration routes
- Route: ORAL; Dosage form: GRANULE; Potency: NASource →
- Route: NASAL; Dosage form: SPRAY, METERED; Potency: 10 mg/1mlSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION; Potency: 2 %w/wSource →
EUCosIngActiveCaffeine is the heterocyclic organic compound that conforms to the formula
- Caffeine is the heterocyclic organic compound that conforms to the formulaSource →
USEPAcommercial use observedEPA CPDat observed this chemical in 921 composition records across product categories including Laboratory supplies, Personal care, Raw materials. EPA CPDat classifies this chemical for functional uses including Deodorizer, Softener and conditioner, Pharmaceutical.
- EPA CPDat observed this chemical in 921 composition records across product categories including Laboratory supplies, Personal care, Raw materials. EPA CPDat classifies this chemical for functional uses including Deodorizer, Softener and conditioner, Pharmaceutical.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 470 active drug products and 497 total products.
- FDA NDC lists this ingredient in 470 active drug products and 497 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
- Flavouring Group Evaluation 49, (FGE.49)1: Xanthin alkaloids from the Priority list from chemical group 30 Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)
  2009 · EU EFSA listing · Read the source →
- Scientific Opinion on Flavouring Group Evaluation 49, Revision 1 (FGE.49Rev1): xanthine alkaloids from the priority list (EFSA CEF)
  2017 · EU EFSA listing · Read the source →
- Scientific Opinion on the safety of caffeine (EFSA NDA)
  2015 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Caffeine yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated march 22, 2013
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA National Drug Code Directory
regulatory · updated 2029-04-30
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (4)

Openfda substance

clinicalkey.com

Read →

Openfda substance

pharmgkb.org

Read →

Openfda substance

accessdata.fda.gov

Read →

Openfda substance

dailymed.nlm.nih.gov

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Caffeine in a product composition. These are source records, not Greenveil catalog products.

Source records

921

Named organisations

Laboratory suppliesPersonal careRaw materialsFood and drugBatteries

Typical roles

Skin conditioningPerfumingFragranceFlavouringConditionerDeodorant

See products using Caffeine →

Catalog

Found in these products

Their ingredient lists include Caffeine; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Caffeine in the catalog.