Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.
- beauty
- cleaning
- pharma
Silybum marianum seed oil
CAS 84604-20-6 · 0/100 · High conf.
Concern score
0/100Low concern — well-established and permitted without restriction (CIR safe as used).
High confidence
Silybum marianum seed oil in plain language
On cosmetic ingredient lists it appears as “Silybum marianum callus extract”.
Also known as Silybum marianum callus extract · Silybum marianum extract · Silybum marianum fruit extract · Silybum marianum powder · Silybum marianum seed extract · Milk thistle extract
Show all 35 names
Silybum marianum · Blessed milk-thistle seed oil · Blessed milkthistle seed oil · Carduus lactifolius seed oil · Carduus mariae seed oil · Carduus marianus seed oil · Carduus versicolor seed oil · Carthamus maculatus seed oil · Centaurea dalmatica seed oil · Cirsium maculatum seed oil · Holy thistle seed oil · Lady's thistle seed oil · Marian thistle seed oil · Mariana lactea seed oil · Mariana mariana seed oil · Mary thistle seed oil · Mediterranean milk thistle seed oil · Milk thistle seed oil · Saint mary's thistle seed oil · Silybum maculatum seed oil · Silybum mariae seed oil · Silybum pygmaeum seed oil · Spotted thistle seed oil · Variegated thistle seed oil · Flavopherol · Lady's thistle (Silybum marianum L. Gaertner) · Milk thistle extracts · Silybum marianum extracts · silybum marianum, ext.
Used in cosmetics as an emollient, a skin-conditioning agent and a skin protectant. Silybum Marianum Callus Extract is the extract of the callus of Silybum marianum grown in culture, Asteraceae.
- Emollient
- Skin conditioning
- Skin protecting
- Humectant
- Conditioner
- Low concern: no hazard classifications on record. It is listed for cosmetic use in the EU.
Why it's flagged
EPA CPDat observed this chemical in 45 composition records across product categories including Personal care.
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Regulation
No restrictions found. Silybum marianum seed oil appears in these published regulatory listings.
- In marketed US drugs
- Found in consumer products
- Beauty
- Cleaning
EUCosIngActive6 entries
- Silybum Marianum Callus Extract is the extract of the callus of Silybum marianum grown in culture, Asteraceae.Source →
- Silybum Marianum Extract is an extract of the seeds and leaves of the Lady's Thistle, Silybum marianum (L.), AsteraceaeSource →
- Silybum Marianum Fruit Extract is an extract of the fruit of the Lady's Thistle, Silybum marianum (L.), AsteraceaeSource →
- Silybum Marianum Powder is the powder obtained from the dried, ground whole plant, Silybum marianum, Asteraceae.Source →
- Silybum Marianum Seed Extract is an extract of the seeds of the Lady's Thistle, Silybum marianum (L.), AsteraceaeSource →
- Silybum Marianum Seed Oil is the fixed oil expressed from the seeds of the Lady's Thistle, Silybum marianum (L.), AsteraceaeSource →
USEPAcommercial use observedEPA CPDat observed this chemical in 45 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Humectant.
- EPA CPDat observed this chemical in 45 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Humectant.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 1 drug products and 1 package presentations.
- FDA NDC lists this ingredient in 1 drug products and 1 package presentations.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as structurallydiverse.
- openFDA substance registry classifies this ingredient as structurallydiverse.Source →
Expert safety opinions
No expert opinion on file for Silybum marianum seed oil. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
Evidence & sources
No graded research studies for Silybum marianum seed oil yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
CosIng
regulatory · updated 2026-09-23
- Open →
EPA Chemical and Products Database
exposure · updated November 2016
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA National Drug Code Directory
regulatory · updated 2026-12-22
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
openFDA Substance
registry · updated 2026-05-24
Allergen profile
Canonical allergen markers detected on this ingredient. Each row is derived from the ingredient’s name or synonyms matching a known allergen class — useful when scanning a label for a specific allergy context.
- DairyContains · Oral (ingested)
Source: chemindex_name_match
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Good fit
Where it has been recorded
How often EPA CPDat has listed Silybum marianum seed oil in a product composition. These are source records, not Greenveil catalog products.
Source records
45
Named organisations
6
Personal care
Typical roles
EmollientSkin conditioningSkin protectingHumectantConditioner
Found in these products
Their ingredient lists include Silybum marianum seed oil; each product's own rating depends on its whole formula, so it is shown on the product page, not here.
- Seedlip Slices x8The Heart of Nature · Plant Based Foods And Beverages
- cleanance comedomedAvène · Non Food Products
- clearance ComedomedAvène
- Strawberry Lemonade Monster RehabMonster · Beverages And Beverages Preparations
- ORIGINAL ROCKSTAR ENERGY DRINKROCKSTAR · Beverages
- Rockstar Recovery LemonadeRockstar
- PURE ZERO FRUIT PUNCH SUGAR FREE ENERGY DRINKROCKSTAR · Beverages And Beverages Preparations
- Opti fitPowdered Juice
- Organic Loaf Slices - Hemp SeedsSeedful · Plant Based Foods And Beverages
- Cleanance Cleansing GelAvène
- Rockstar Focus orange pineappleRockstar
- PineappleRockstar Punched · Beverages And Beverages Preparations
- Rehab Monster Green TeaMonster · Beverages And Beverages Preparations
- Energy drinkRockstar · Beverages
- Energy DrinkRockstar, Rockstar Inc. · Beverages
- Sugar free energy drinkBeverages
- Energy drink, fruit punchRockstar Inc. · Beverages
- Silver Ice, Pure ZeroRockstar · Beverages
- ENERGY DRINKROCKSTAR · Beverages And Beverages Preparations
- WHIPPED STRAWBERRY ENERGY DRINKROCKSTAR BOOM
- Rockstar juiced island mangoRockstar · Beverages
- Morning RecoveryDietary Supplements
- Dose for your liver
- BIO LYTE PREMIUM ELECTROLYTE SUPPLEMENTBIO LYTE
Often appears with
Ingredients that frequently appear alongside Silybum marianum seed oil in the catalog.