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Pyridoxine hydrochloride

CAS 8064-77-5 · 40/100 · High conf.

Also registered as 2 other CAS numbers

58-56-0 · 12001-77-3

Pyridoxine hydrochloride chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Pyridoxine hydrochloride in plain language

What it is

On cosmetic ingredient lists it appears as “Pyridoxine hcl”.

Also known as Pyridoxine hcl · 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;hydrochloride · Pyridoxine chloride · Pyridoxol hydrochloride · Vitamin B6 hydrochloride · 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride

Show all 36 names

3-Hydroxy-4,5-dimethylol-α-picoline hydrochloride · 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride · Aderoxin · Aderoxine · Alestrol · Becilan · Beesix · Benadon · Bonasanit · Campoviton 6 · Godabion · Hexa-betalin · Hexabetalin · Hexavibex · Hexermin · Hexobion · Pydox · Pyridipca · Thiamine mononitrate · pyridoxine hydrochloride 100 mg/ml · pyridoxine hydrochloride (b6) · pyridoxine hydrochloride - 50 mg/vial · pyridoxini hydrchloridum · Pyridoxinum hydrochloricum · Tpn component pyridoxine hydrochloride · Vitamin B6 (as pyridoxine hydrochloride) · Bendectin component pyridoxine hydrochloride · Bonjesta component pyridoxine hydrochloride · Diclectin component pyridoxine hydrochloride · Diclegis component pyridoxine hydrochloride

What it does

Used in cosmetics as a skin-conditioning agent, a hair conditioner and an antistatic agent.

  • Skin conditioning
  • Hair conditioning
  • Antistatic
  • Flavouring
  • Conditioner
Is it a concern?
Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 355 composition records across product categories including Food and drug, Personal care, Raw materials.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Pyridoxine hydrochloride appears in these published regulatory listings.

  • In marketed US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • Industrial
  • EUEFSAEFSA opinion3 entries
    • Scientific Opinion on the safety and efficacy of vitamin B6 as a feed additive for all animal species (EFSA FEEDAP)Source →
    • Assessment of the application for renewal of authorisation of pyridoxine hydrochloride (vitamin B6) as a feed additive for all animal species (EFSA FEEDAP)Source →
    • Scientific Opinion on the safety and efficacy of vitamin B6 (pyridoxine hydrochloride) as a feed additive for all animal species (EFSA FEEDAP)Source →
  • USFDAmarketed drug occurrence2 entries
    • FDA NDC lists this ingredient in 1 active drug products and 1 total products.Source →
    • FDA NDC lists this ingredient in 127 active drug products and 142 total products.Source →
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 355 composition records across product categories including Food and drug, Personal care, Raw materials. EPA CPDat classifies this chemical for functional uses including Anti-static agent, Softener and conditioner, Pharmaceutical.
    • EPA CPDat observed this chemical in 355 composition records across product categories including Food and drug, Personal care, Raw materials. EPA CPDat classifies this chemical for functional uses including Anti-static agent, Softener and conditioner, Pharmaceutical.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Scientific Opinion on the safety and efficacy of vitamin B6 as a feed additive for all animal species (EFSA FEEDAP)

      2010 · EU EFSA listing · Read the source →

    • Assessment of the application for renewal of authorisation of pyridoxine hydrochloride (vitamin B6) as a feed additive for all animal species (EFSA FEEDAP)

      2020 · EU EFSA listing · Read the source →

    • Scientific Opinion on the safety and efficacy of vitamin B6 (pyridoxine hydrochloride) as a feed additive for all animal species (EFSA FEEDAP)

      2011 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Pyridoxine hydrochloride yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated September 2018

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2026-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (5)
Openfda substance

accessdata.fda.gov

Read →
Openfda substance

drugoffice.gov.hk

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Pyridoxine hydrochloride in a product composition. These are source records, not Greenveil catalog products.

Source records

355

Named organisations

6

Food and drugPersonal careRaw materials

Typical roles

Skin conditioningHair conditioningAntistaticFlavouringConditioner
See products using Pyridoxine hydrochloride →

Catalog

Found in these products

Their ingredient lists include Pyridoxine hydrochloride; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Pyridoxine hydrochloride in the catalog.