What does Glucuronolactone do?

Used in cosmetics as a skin-conditioning agent.

Is Glucuronolactone safe?

Minor concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

beauty
cleaning
food

Glucuronolactone

CAS 63-29-6 · 20/100 · High conf.

Also registered as 5 other CAS numbers

3428-13-5 · 4214-08-8 · 6814-06-8 · 10030-64-5 · 32449-92-6

Concern score

20/100Minor concern based on regulatory listings.

High confidence

Glucuronolactone in plain language

What it is: Also known as Glucurolactone · D-glucuronolactone · D-Glucurono-gamma-lactone · .gamma-lactone of d-glucofuranuronic acid · D-(+)-Glucuronic acid γ-lactone · gamma-lactone D-Glucofuranuronic acid
Show all 19 names
D-Glucurone · D-Glucuronic acid lactone · gamma-lactone D-Glucuronic acid · D-Glucurono-6,3-lactone · Dicurone · Guronsan · Glucoxy · Glucurolactona · Glucurolactonum · Glucurone · Glucuronolattone · Glucuronosan · Gluronsan
What it does: Used in cosmetics as a skin-conditioning agent.
Skin conditioning
Humectant
Conditioner
Is it a concern?: Minor concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 8 composition records across product categories including Personal care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Glucuronolactone appears in these published regulatory listings.

Recorded in these product areas

Found in consumer products
Beauty
Cleaning

EUCosIngActiveD-Glucuronic acid, .gamma.-lactone
- D-Glucuronic acid, .gamma.-lactoneSource →
EUEFSAEFSA opinionThe use of taurine and D-glucurono-gamma-lactone as constituents of the so-called “energy” drinks (EFSA ANS)
- The use of taurine and D-glucurono-gamma-lactone as constituents of the so-called “energy” drinks (EFSA ANS)Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 8 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Humectant.
- EPA CPDat observed this chemical in 8 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Humectant.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
- The use of taurine and D-glucurono-gamma-lactone as constituents of the so-called “energy” drinks (EFSA ANS)
  2009 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Glucuronolactone yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated July 2015
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Glucuronolactone in a product composition. These are source records, not Greenveil catalog products.

Source records

Named organisations

Personal care

Typical roles

Skin conditioningHumectantConditioner

See products using Glucuronolactone →

Catalog

Found in these products

Their ingredient lists include Glucuronolactone; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 675 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Glucuronolactone in the catalog.