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Trisodium citrate dihydrate

CAS 943143-17-7 · 0/100 · High conf.

Also registered as 5 other CAS numbers

2594426-28-3 · 2697169-41-6 · 2768336-37-2 · 68-04-2 · 6132-04-3

Trisodium citrate dihydrate chemical structure

Concern score

0/100Low concern — well-established and permitted without restriction (FDA GRAS; JECFA ADI not specified; CIR safe as used; EU food additive; EU CosIng).
High confidence

Trisodium citrate dihydrate in plain language

What it is

On cosmetic ingredient lists it appears as “Sodium citrate”.

Also known as Sodium citrate · Sodium citrate dihydrate · Sodium citrate hydrate · Sodium citrate hydrous · Dihydrate sodium citrate · Citric acid, trisodium salt, dihydrate

Show all 28 names

Sodium 2-hydroxypropane-1,2,3-tricarboxylate--water (3/1/2) · trisodium;2-hydroxypropane-1,2,3-tricarboxylate;dihydrate · Anticoagulant Sodium Citrate · Citrate, sodium, dihydrate · Citrate, trisodium, 2-HYDRATE · CVS Health · CVS Health Nausea Relief · Emetrol Chewables · Emetrol Chewables Mixed Berry · Emetrol Chewables Orange · Emetrol Powder · Emetrol Powder Non-Drowsy · N-1560 · Natriumcitrat-dihydrat · Nauzene · Nauzene Chewables · Tricitrasol · Trisodium citrate · natrii citras · sodium citrate (hydrated form) · sodium citrate. % wt: 100 gm/l · dehydrate Natrii citras

What it does

Used in cosmetics as a pH buffer, a chelating agent and a fragrance ingredient.

  • Buffering
  • Chelating
  • Fragrance
  • Preservative
  • Chelating agent
  • pH adjuster
Is it a concern?
Low concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 261 composition records across product categories including Laboratory supplies, Food and drug, Cleaning products and household care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Trisodium citrate dihydrate appears in these published regulatory listings.

  • In marketed US drugs
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • Industrial
  • USFDAinactive ingredient database47 entries — 16 administration routes
    • Route: INTRACAVERNOUS; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Potency: 0.03 mgSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION; Maximum daily exposure: 3480 mgSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 1188 mgSource →
    • Route: INTRAMUSCULAR; Dosage form: SOLUTION; Potency: 0.03 %w/vSource →
    • Route: INTRAOCULAR; Dosage form: INJECTION, SOLUTION, CONCENTRATE; Potency: 5.48 mg/1mlSource →
    • Route: INTRAOCULAR; Dosage form: SOLUTION; Maximum daily exposure: 27 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION; Maximum daily exposure: 3480 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Maximum daily exposure: 800 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 1188 mgSource →
    • Route: INTRAVENOUS; Dosage form: SOLUTION; Maximum daily exposure: 41 mgSource →
    • Route: INTRAVITREAL; Dosage form: INJECTION, SUSPENSION; Potency: 0.17 %w/vSource →
    • Route: IRRIGATION; Dosage form: INJECTION, SOLUTION, CONCENTRATE; Potency: 0.55 %w/vSource →
    • Route: NASAL; Dosage form: SPRAY; Maximum daily exposure: 9 mgSource →
    • Route: NASAL; Dosage form: SPRAY, METERED; Maximum daily exposure: 1 mgSource →
    • Route: OPHTHALMIC; Dosage form: SOLUTION; Potency: 0.45 %w/vSource →
    • Route: OPHTHALMIC; Dosage form: SOLUTION/ DROPS; Maximum daily exposure: 1 mgSource →
    • Route: OPHTHALMIC; Dosage form: SUSPENSION/ DROPS; Maximum daily exposure: 7 mgSource →
    • Route: ORAL; Dosage form: CAPSULE; Maximum daily exposure: 35 mgSource →
    • Route: ORAL; Dosage form: CONCENTRATE; Maximum daily exposure: 104 mgSource →
    • Route: ORAL; Dosage form: ELIXIR; Maximum daily exposure: 68 mgSource →
    • Route: ORAL; Dosage form: GRANULE, FOR SUSPENSION; Maximum daily exposure: 4950 mgSource →
    • Route: ORAL; Dosage form: POWDER, FOR SUSPENSION; Maximum daily exposure: 5010 mgSource →
    • Route: ORAL; Dosage form: SOLUTION; Maximum daily exposure: 1200 mgSource →
    • Route: ORAL; Dosage form: SUSPENSION; Maximum daily exposure: 5013 mgSource →
    • Route: ORAL; Dosage form: SUSPENSION, EXTENDED RELEASE; Maximum daily exposure: 9 mgSource →
    • Route: ORAL; Dosage form: SYRUP; Maximum daily exposure: 705 mgSource →
    • Route: ORAL; Dosage form: TABLET; Maximum daily exposure: 896 mgSource →
    • Route: ORAL; Dosage form: TABLET, CHEWABLE; Maximum daily exposure: 14 mgSource →
    • Route: ORAL; Dosage form: TABLET, DELAYED RELEASE; Maximum daily exposure: 640 mgSource →
    • Route: ORAL; Dosage form: TABLET, EXTENDED RELEASE; Maximum daily exposure: 300 mgSource →
    • Route: ORAL; Dosage form: TABLET, FILM COATED, EXTENDED RELEASE; Maximum daily exposure: 200 mgSource →
    • Route: RECTAL; Dosage form: SOLUTION; Maximum daily exposure: 773 mgSource →
    • Route: RESPIRATORY (INHALATION); Dosage form: POWDER; Maximum daily exposure: 17 mgSource →
    • Route: RESPIRATORY (INHALATION); Dosage form: SOLUTION; Maximum daily exposure: 24 mgSource →
    • Route: RESPIRATORY (INHALATION); Dosage form: SUSPENSION; Maximum daily exposure: 2 mgSource →
    • Route: SUBCUTANEOUS; Dosage form: INJECTION; Maximum daily exposure: 75 mgSource →
    • Route: SUBCUTANEOUS; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 28 mgSource →
    • Route: SUBLINGUAL; Dosage form: FILM; Maximum daily exposure: 7 mgSource →
    • Route: SUBLINGUAL; Dosage form: TABLET; Maximum daily exposure: 51 mgSource →
    • Route: TOPICAL; Dosage form: CLOTH; Maximum daily exposure: 2 mgSource →
    • + 7 more entries not shown
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • GLOBALJECFAEvaluatedJECFA evaluation record.
  • USEPAcommercial use observedEPA CPDat observed this chemical in 261 composition records across product categories including Laboratory supplies, Food and drug, Cleaning products and household care. EPA CPDat classifies this chemical for functional uses including Chelating agent, pH regulating agent, Preservative.
    • EPA CPDat observed this chemical in 261 composition records across product categories including Laboratory supplies, Food and drug, Cleaning products and household care. EPA CPDat classifies this chemical for functional uses including Chelating agent, pH regulating agent, Preservative.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 45 active drug products and 45 total products.
    • FDA NDC lists this ingredient in 45 active drug products and 45 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

Evidence & sources

No graded research studies for Trisodium citrate dihydrate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated october 17, 2014

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • WHO JECFA Database

    regulatory · updated 2026-10-04

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (2)
Openfda substance

en.wikipedia.org

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Trisodium citrate dihydrate in a product composition. These are source records, not Greenveil catalog products.

Source records

261

Named organisations

6

Laboratory suppliesFood and drugCleaning products and household careCleaning and safetyIndustrial productsPersonal care

Typical roles

BufferingChelatingFragrancePreservativeChelating agentpH adjuster
See products using Trisodium citrate dihydrate →

Catalog

Found in these products

Their ingredient lists include Trisodium citrate dihydrate; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Trisodium citrate dihydrate in the catalog.