Food use
Food-use source coverage is present in the current record.
The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.
Niacinamide
EPA CPDat observed this chemical in 2264 composition records across product categories including Food and drug, Laboratory supplies, Personal care.
Research docs2Claims4Sources16Functionskin conditioning • skin conditioningIdentifierAI-0098-92-0
Concern score
25/100Minor concern informed by published safety evidence.
Well researched
Efficacy · Efficacy 35Safety · No scored signal
How we scored this
The concern value reflects this ingredient's chemical identity — its hazard profile from the published classifications and regulatory status below — not the safety of a product it appears in. A score near 40 is the baseline for ingredients with no specific signal (water scores 40 by design), so a mid-range value is not a safety verdict.
Concern score 25/100 (minor) · high confidence · backed by 2 documents and 4 studyies.
Where it appears
Prevalence of Niacinamide in our catalog (epa_cpdat).
Products
2,264
Brands
6
Food and drugLaboratory suppliesPersonal care
Typical roles
skin conditioningskin conditioningCosmetic IngredientFlavouring and nutrientHumectantSoftener and conditioner
Catalog
Found in these products
Co-occurrence
Often appears with
Ingredients that frequently appear alongside Niacinamide in the catalog.
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Good fit
Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
Linked research
Primary documents currently linked to this ingredient record.
| Document | Published |
|---|---|
Open access review of niacinamide formulation use PMC / PMC2000001 View public researchOpen-access article reporting clinical and formulation evidence for niacinamide tolerability and barrier-support activity in skincare. | 2024-04-12 |
Topical niacinamide and skin barrier outcomes PubMed / 1000001 View public researchReview of topical niacinamide use showing repeated support for barrier-strength and tolerability outcomes in leave-on skincare. | 2024-05-01 |
Extracted claims
Structured claim signals pulled from linked ingredient research.
| Domain | Claim | Confidence |
|---|---|---|
| Efficacy | transepidermal water loss Topical niacinamide reduced TEWL versus vehicle in a six-week trial. | 94% Clinical trial |
| Safety | tolerability Participants reported good tolerability for niacinamide serum use. | 90% Clinical trial |
| Efficacy | skin barrier strength Consistent improvement in barrier-support outcomes across reviewed topical niacinamide studies. |
Regulatory status
Published jurisdiction-level classifications and regulatory designations for this ingredient.
US
EPA
EPA CPDat observed this chemical in 2264 composition records across product categories including Food and drug, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, Cosmetic Ingredient.
