Open access review of niacinamide formulation use
Open-access article reporting clinical and formulation evidence for niacinamide tolerability and barrier-support activity in skincare.
- beauty
- cleaning
- food
- industrial
Niacinamide
CAS 11032-50-1 · 25/100 · High conf.
Skin conditioning · Cosmetic Ingredient · Flavouring and nutrient
Concern score
25/100Minor concern informed by published safety evidence.
Well researched
Why it's flagged
EPA CPDat observed this chemical in 2264 composition records across product categories including Food and drug, Laboratory supplies, Personal care.
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Regulation
No restrictions found. Niacinamide appears in these published regulatory listings.
- commercial_presence
- consumer_product_presence
- cpdat_category:beauty|cleaning|pharma|food|industrial
- currently_marketed_ndc
- definition_level:complete
- definition_type:primary
- inactive_ingredient_database
- ingredient_type:ingredient substance
USFDAinactive ingredient database4 entries — 3 administration routes
AUAICISListedIndustrial chemical listed for Australian introduction.
- Industrial chemical listed for Australian introduction.Source →
AUTGAPermittedListed in approved ingredient terminology.
- Listed in approved ingredient terminology.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 2264 composition records across product categories including Food and drug, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, Cosmetic Ingredient.
- EPA CPDat observed this chemical in 2264 composition records across product categories including Food and drug, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, Cosmetic Ingredient.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 190 active drug products and 216 total products.
- FDA NDC lists this ingredient in 190 active drug products and 216 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Evidence
The graded sources and structured signals behind this record.
Evidence snapshot
- 94%
EfficacyEfficacy 35
2 docs / 2 studies
- 93%
SafetyNo scored signal
2 docs / 2 studies
Topical niacinamide and skin barrier outcomes
Review of topical niacinamide use showing repeated support for barrier-strength and tolerability outcomes in leave-on skincare.
Extracted claims
Structured claim signals pulled from linked ingredient research.
transepidermal water lossEfficacy
Topical niacinamide reduced TEWL versus vehicle in a six-week trial.
94%Clinical trial
tolerabilitySafety
Participants reported good tolerability for niacinamide serum use.
90%Clinical trial
skin barrier strengthEfficacy
Consistent improvement in barrier-support outcomes across reviewed topical niacinamide studies.
92%Narrative review
local tolerabilitySafety
Review reports niacinamide as generally well tolerated in topical use.
90%Narrative review
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Food use
Food-use source coverage is present in the current record.
The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.
Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.
Where it appears
Prevalence of Niacinamide in our catalog (epa_cpdat).
Products
2,264
Brands
6
Food and drugLaboratory suppliesPersonal care
Typical roles
Skin conditioningCosmetic IngredientFlavouring and nutrientHumectantSoftener and conditioner
Found in these products
- CeraVe Schuimende ReinigingsgelCeraVe · BeautyMinor
- Foaming cleanserL'Oréal,Cerave · Non Food ProductsLow
- Blemish control cleanserCerave,L'OréalCritical
- Lipikar Baume AP+ MLa Roche-Posay,loreal · BodyLow
- CeraVe SPF50 Hydraterende Gezichtscrèmecerave · BeautyLow
- Loción Corporal HidrataDeliplus · BeautyHigh
- Anti manchasDeliplusMinor
- shampooclear · Open Beauty FactsCritical
- facial cleanDeliplus · Non Food ProductsHigh
- head and shoulders classicHead & Shoulders · Non Food ProductsCritical
- SVR Spray Sun Secure SPF 50+SVR · SuncareLow
- Stimulating shampooDercos · Non Food ProductsHigh
- SA Smoothing CleanserCeraVeCritical
- Effaclar duo+La Roche-Posay · 3337875863377Critical
- LIPIKAR BAUME AP+MLa Roche-Posay · BodyLow
- centella sun creamNon Food ProductsLow
- Vaseline daily brighteningNon Food ProductsCritical
- Garnier Ultra DOUXCritical
- Lucky CharmsLucky Charms · Plant Based Foods And BeveragesCritical
- General mills total whole grain flakesGeneral Mills · Plant Based Foods And BeveragesModerate
- nesquikNestlé · Beverages And Beverages PreparationsMinor
- Loción corporal calmDeliplus · Non Food ProductsHigh
- Crème protectrice visageCorine de Farme · SuncareMinor
- Corn ChexGeneral Mills · Plant Based Foods And BeveragesModerate
Often appears with
Ingredients that frequently appear alongside Niacinamide in the catalog.