What does Niacinamide do?

Used in cosmetics as a smoothing agent.

Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

beauty
cleaning
food
industrial

Niacinamide

CAS 98-92-0 · 40/100 · High conf.

Also registered as 5 other CAS numbers

11032-50-1 · 1255150-40-3 · 37321-14-5 · 78731-47-2 · 123574-63-0

Concern score

40/100Moderate concern based on regulatory listings.

High confidence

Niacinamide in plain language

What it is: Also known as Nicotinamide · Niacinamid · Niacinamide B3 · Pyridine-3-carboxamide · Vitamin B3 · 3-(Aminocarbonyl)pyridine
Show all 34 names
3-Amidopyridine · 3-Carbamoylpyridine · 3-Pyridinecarboxamide · 3-Pyridinecarboxylic acid amide · Aminicotin · Amixicotyn · Benicot · Dipegyl · Endobion · Hansamid · Nam · Nicamindon · Nicobion · Nicofort · Nicotilamide · Nicotinic acid amide · Nikotinamid · Niozymin · Papulex · Pelmine · Pelonin amide · Savacotyl · niacinamide (b3) · niacinamide - 750 mg/vial · vitamin b · Niacin (as niacinamide) · Nicotinamidum · Tpn component niacinamide
What it does: Used in cosmetics as a smoothing agent.
Smoothing
Skin conditioning
Humectant
Flavouring
Conditioner
Is it a concern?: Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

Fetched 1 ClinicalTrials.gov references for Niacinamide.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Niacinamide appears in these published regulatory listings.

In marketed US drugs
Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Pharma
Food
Industrial

EUEFSAEFSA opinion6 entries
- Scientific Opinion on Dietary Reference Values for niacin (EFSA NDA)Source →
- Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by VITAC EEIG (EFSA FEEDAP)Source →
- Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by Vertellus Specialties Belgium BV (EFSA FEEDAP)Source →
- Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by Lonza Benelux BV (EFSA FEEDAP)Source →
- Scientific Opinion on the safety and efficacy of niacin (nicotinamide) as a feed additive for all animal species based on a dossier submitted by EUROPE-ASIA Import Export GmbH (EFSA FEEDAP)Source →
- Scientific Opinion on the safety and efficacy of niacin (nicotinamide) as feed additive for all animal species based on a dossier submitted by Agrinutrition BV (EFSA FEEDAP)Source →
USFDAinactive ingredient database4 entries — 3 administration routes
- Route: TOPICAL; Dosage form: CREAM; Potency: NASource →
- Route: TOPICAL; Dosage form: GEL; Maximum daily exposure: 25 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 2.5 %w/vSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION; Potency: 2.5 %w/vSource →
AUAICISListedIndustrial chemical listed for Australian introduction.
- Industrial chemical listed for Australian introduction.Source →
AUTGAPermittedListed in approved ingredient terminology.
- Listed in approved ingredient terminology.Source →
EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
EUEFSAReport from international authorityOpinion of the Scientific Committee on Food on the Tolerable Upper Intake Levels of Nicotinic Acid and Nicotinamide (Niacin) (SCF)
- Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Levels of Nicotinic Acid and Nicotinamide (Niacin) (SCF)Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 2264 composition records across product categories including Food and drug, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, Cosmetic Ingredient.
- EPA CPDat observed this chemical in 2264 composition records across product categories including Food and drug, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, Cosmetic Ingredient.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 190 active drug products and 216 total products.
- FDA NDC lists this ingredient in 190 active drug products and 216 total products.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
- Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Levels of Nicotinic Acid and Nicotinamide (Niacin) (SCF)
  2002 · EU EFSA listing · Read the source →
- Scientific Opinion on Dietary Reference Values for niacin (EFSA NDA)
  2014 · EU EFSA listing · Read the source →
- Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by VITAC EEIG (EFSA FEEDAP)
  2012 · EU EFSA listing · Read the source →
- Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by Vertellus Specialties Belgium BV (EFSA FEEDAP)
  2012 · EU EFSA listing · Read the source →
- Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by Lonza Benelux BV (EFSA FEEDAP)
  2012 · EU EFSA listing · Read the source →
- Scientific Opinion on the safety and efficacy of niacin (nicotinamide) as a feed additive for all animal species based on a dossier submitted by EUROPE-ASIA Import Export GmbH (EFSA FEEDAP)
  2012 · EU EFSA listing · Read the source →
- Scientific Opinion on the safety and efficacy of niacin (nicotinamide) as feed additive for all animal species based on a dossier submitted by Agrinutrition BV (EFSA FEEDAP)
  2012 · EU EFSA listing · Read the source →

Evidence & sources

The graded studies and structured signals behind this record.

13 data sources

Where this comes from

AICIS Inventory
regulatory · updated 2026-02-05
Open →
ClinicalTrials.gov
clinical · updated 2026-03-12
Open →
CosIng
regulatory · updated 2026-09-23
Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated november 12, 2010
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA National Drug Code Directory
regulatory · updated 2033-03-14
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem
chemistry · updated 2026-01-15
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →
TGA Ingredients
regulatory · updated 2026-02-07
Open →

Reference links (1)

Clinicaltrials.gov

Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL

Read →

ClinicalTrials.gov · 2022

Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL

This is a phase I trial with pilot expansion of HLA-haploidentical or HLA-mismatched related donor nicotinamide expanded-natural killer (NAM-NK) cell based therapy for patients with relapsed or refractory multiple myeloma (MM) or…

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Niacinamide in a product composition. These are source records, not Greenveil catalog products.

Source records

2,264

Named organisations

Food and drugLaboratory suppliesPersonal care

Typical roles

SmoothingSkin conditioningHumectantFlavouringConditioner

See products using Niacinamide →

Catalog

Found in these products

Their ingredient lists include Niacinamide; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Niacinamide in the catalog.