What does Pyridoxine do?

Used in cosmetics as a skin-conditioning agent, a hair conditioner and an antistatic agent.

Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

beauty
cleaning
food
pharma

Pyridoxine

CAS 12001-77-3 · 40/100 · High conf.

Also registered as 3 other CAS numbers

2087491-32-3 · 65-23-6 · 8059-24-3

Concern score

40/100Moderate concern based on regulatory listings.

High confidence

Pyridoxine in plain language

What it is: Also known as Vitamin B6 · 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol · Adermine · Hexabione · Pyridoxol · Vitamin B-6
Show all 25 names
2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine · 2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine · 2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine · 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-; vitamine B6 · 3-Hydroxy-4,5-dimethylol-alpha-picoline · 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine · 5-Hydroxy-6-methyl-3,4-pyridinedimethanol · Adermin · Bezatin · Gravidox · Hydoxin · Piridossina · Piridoxina · Pirivitol · Pyridoxin · Pyridoxinum · Pyridoxolum · Vitamin V6 · piridoxinio
What it does: Used in cosmetics as a skin-conditioning agent, a hair conditioner and an antistatic agent.
Skin conditioning
Hair conditioning
Antistatic
Conditioner
Is it a concern?: Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 31 composition records across product categories including Personal care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Pyridoxine appears in these published regulatory listings.

In marketed US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning

EUEFSAEFSA opinion3 entries
- Assessment of a feed additive consisting of vitamin B6 (pyridoxine hydrochloride) for all animal species for the renewal of its authorisation (Kaesler Nutrition GmbH) (EFSA FEEDAP)Source →
- Dietary Reference Values for vitamin B6 (EFSA NDA)Source →
- Opinion on Pyridoxal 5'-phosphate as a source for vitamin B6 added for nutritional purposes in food supplements - Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)Source →
EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
EUEFSAReport from international authorityOpinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Vitamin B6 (SCF)
- Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Vitamin B6 (SCF)Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 31 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Anti-static agent, Softener and conditioner.
- EPA CPDat observed this chemical in 31 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Anti-static agent, Softener and conditioner.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 25 active drug products and 26 total products.
- FDA NDC lists this ingredient in 25 active drug products and 26 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
- Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Vitamin B6 (SCF)
  2000 · EU EFSA listing · Read the source →
- Assessment of a feed additive consisting of vitamin B6 (pyridoxine hydrochloride) for all animal species for the renewal of its authorisation (Kaesler Nutrition GmbH) (EFSA FEEDAP)
  2021 · EU EFSA listing · Read the source →
- Dietary Reference Values for vitamin B6 (EFSA NDA)
  2016 · EU EFSA listing · Read the source →
- Opinion on Pyridoxal 5'-phosphate as a source for vitamin B6 added for nutritional purposes in food supplements - Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)
  2008 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Pyridoxine yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated September 2018
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (1)

Openfda substance

accessdata.fda.gov

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Pyridoxine in a product composition. These are source records, not Greenveil catalog products.

Source records

Named organisations

Personal care

Typical roles

Skin conditioningHair conditioningAntistaticConditioner

See products using Pyridoxine →

Catalog

Found in these products

Their ingredient lists include Pyridoxine; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Pyridoxine in the catalog.