- food
- industrial
- pharma
L-Tryptophan
CAS 73-22-3 · 40/100 · High conf.
Also registered as 6 other CAS numbers
202406-50-6 · 6912-86-3 · 80206-30-0 · 154635-35-5 · 2416148-24-6 · 2831375-12-1
Concern score
40/100Moderate concern based on regulatory listings.
High confidence
L-Tryptophan in plain language
Also known as Tryptophan · (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid · L-.ALPHA.-AMINO-3-INDOLEPROPIONIC acid · Tryptophan ((-),l,s) · Trytophan- · (S)-2-AMINO-3-(3-INDOLYL)PROPIONIC acid
Show all 32 names
(S)-2-Amino-3-(1H-indol-3-yl)propanoic acid · (S)-Tryptophan · (S)-α-Amino-1H-indole-3-propanoic acid · 1-beta-3-Indolylalanine · 1H-INDOLE-3-PROPANOIC acid, .alpha.-amino-, (s)- · 1H-Indole-3-alanine · 1beta-3-Indolylalanine · 3-Indol-3-ylalanine · Ardeytropin · Indole-3-alanine · L- Tryptophan · L-tryptophan (amino acid) · L-Trp · L-Tryptofan · L-Tryptophane · L-beta-3-Indolylalanine · Pacitron · Tryptophan, l- · Triptophan · Tryptophane · Tryptophanum · amino acids: l-tryptophan · l-trypothan · triptofano · trofan · tryptacin
Used in consumer products as a flavouring.
- Flavouring
- Moderate concern: no hazard classifications on record.
Why it's flagged
EPA CPDat observed this chemical in 3 composition records across product categories including Raw materials.
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Regulation
No restrictions found. L-Tryptophan appears in these published regulatory listings.
- In marketed US drugs
- Inactive ingredient in US drugs
- Found in consumer products
- Industrial
EUEFSAEFSA opinion7 entries
- Scientific opinion on the safety and efficacy of L-tryptophan produced by Escherichia coli (FERM BP-11200) for all animal species based on a dossier submitted by Ajinomoto Eurolysine SAS (EFSA FEEDAP)Source →
- Safety of L-tryptophan produced by fermentation with Escherichia coli CGMCC 7.59 for all animal species based on a dossier submitted by Feedway Europe NV (EFSA FEEDAP)Source →
- Safety of L-tryptophan produced by fermentation using Escherichia coli CGMCC 3667, for all animal species based on a dossier submitted by GBT Europe GmbH (EFSA FEEDAP)Source →
- Scientific Opinion on the safety and efficacy of L-tryptophan, technically pure, produced by Escherichia coli strains DSM 25084, KCCM 11132P or SARI12091203 for all animal species based on a dossier submitted by AMAC EEIG (EFSA FEEDAP)Source →
- Scientific Opinion on the safety and efficacy of L-tryptophan produced by Escherichia coli CGMCC 7.59 for all animal species based on a dossier submitted by HELM AG on behalf of Meihua Holdings Co. Ltd (EFSA FEEDAP)Source →
- Scientific Opinion on the safety and efficacy of L-tryptophan technically pure produced by fermentation with Escherichia coli for all animal species, based on a dossier submitted by HELM AG on behalf of Global Bio-Chem Technology (EFSA FEEDAP)Source →
- Safety of L-tryptophan technically pure, produced by Escherichia coli CGMCC 3667, for all animal species based on a dossier submitted by GBT Europe GmbH (EFSA FEEDAP)Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 3 composition records across product categories including Raw materials. EPA CPDat classifies this chemical for functional uses including Flavouring and nutrient.
- EPA CPDat observed this chemical in 3 composition records across product categories including Raw materials. EPA CPDat classifies this chemical for functional uses including Flavouring and nutrient.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 73 active drug products and 75 total products.
- FDA NDC lists this ingredient in 73 active drug products and 75 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Expert safety opinions
Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.
JECFA
Joint FAO/WHO Expert Committee on Food Additives
No JECFA evaluation on file.
EFSA
European Food Safety Authority
Scientific opinion on the safety and efficacy of L-tryptophan produced by Escherichia coli (FERM BP-11200) for all animal species based on a dossier submitted by Ajinomoto Eurolysine SAS (EFSA FEEDAP)
2013 · EU EFSA listing · Read the source →
Safety of L-tryptophan produced by fermentation with Escherichia coli CGMCC 7.59 for all animal species based on a dossier submitted by Feedway Europe NV (EFSA FEEDAP)
2016 · EU EFSA listing · Read the source →
Safety of L-tryptophan produced by fermentation using Escherichia coli CGMCC 3667, for all animal species based on a dossier submitted by GBT Europe GmbH (EFSA FEEDAP)
2016 · EU EFSA listing · Read the source →
Scientific Opinion on the safety and efficacy of L-tryptophan, technically pure, produced by Escherichia coli strains DSM 25084, KCCM 11132P or SARI12091203 for all animal species based on a dossier submitted by AMAC EEIG (EFSA FEEDAP)
2015 · EU EFSA listing · Read the source →
Scientific Opinion on the safety and efficacy of L-tryptophan produced by Escherichia coli CGMCC 7.59 for all animal species based on a dossier submitted by HELM AG on behalf of Meihua Holdings Co. Ltd (EFSA FEEDAP)
2015 · EU EFSA listing · Read the source →
Scientific Opinion on the safety and efficacy of L-tryptophan technically pure produced by fermentation with Escherichia coli for all animal species, based on a dossier submitted by HELM AG on behalf of Global Bio-Chem Technology (EFSA FEEDAP)
2014 · EU EFSA listing · Read the source →
Safety of L-tryptophan technically pure, produced by Escherichia coli CGMCC 3667, for all animal species based on a dossier submitted by GBT Europe GmbH (EFSA FEEDAP)
2017 · EU EFSA listing · Read the source →
Evidence & sources
No graded research studies for L-Tryptophan yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
- Open →
EPA Chemical and Products Database
exposure · updated January 7, 2008
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
- Open →
FDA National Drug Code Directory
regulatory · updated 2028-10-03
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Food use
Food-use source coverage is present in the current record.
The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.
Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.
Where it has been recorded
How often FDA National Drug Code directory has listed L-Tryptophan in a product composition. These are source records, not Greenveil catalog products.
Source records
75
Typical roles
Flavouring
Found in these products
Their ingredient lists include L-Tryptophan; each product's own rating depends on its whole formula, so it is shown on the product page, not here.
- Primalac 1,, · Dairies
- Lait infantileHipp · Baby Foods
- GUIGOZ 3 BIO Croissance 800gNestlé, Guigoz · Baby Foods
- Protein OatsDoctor's Choice · Plant Based Foods And Beverages
- 1 First Baby Milk Formula From BirthBaby Foods
- Follow on milkAptamil · Baby Foods
- Burger PattiesImpossible
- Goat Infant FormulaKendamil · Baby Foods
- Sausage made from plantsImpossible
- BURGER PATTIESIMPOSSIBLE · Meat Alternatives
- Baby formulaKendamil · Baby Foods
- Lait maternel de chèvreHolle · Baby Foods
- Collagen PeptidesVital Proteins · Dietary Supplements
- Aptamil 3Baby Foods
- Croissance bio 3Carrefour
- First Infant MilkHiPP · Baby Foods
- Prebabylove
- Similac Pro AdvanceAbbott · Baby Foods
- Powder 12.1 Oz Can 6 CountAbbott
- Hydrolyzed Collagen PowderTrader Joe's · Dietary Supplements
- Burger made from plantsImpossible Foods · Meat Alternatives
- Steak BitesImpossible · Meat Alternatives
- Similac Advance Step 1 Concentrated Liquid Milk-Based Iron Fortified Infant FormulaAbott · Baby Foods
- Astheplex3CPharma · Dietary Supplements
Often appears with
Ingredients that frequently appear alongside L-Tryptophan in the catalog.