beauty
cleaning
food
industrial

Proline

CAS 147-85-3 · 60/100 · High conf.

Also registered as 5 other CAS numbers

4305-67-3 · 37159-97-0 · 7005-20-1 · 95650-41-2 · 1150316-19-0

Concern score

60/100High concern based on regulatory listings.

High confidence

Proline in plain language

What it is: Also known as L-Proline · (2S)-pyrrolidine-2-carboxylic acid · L-2-Pyrrolidinecarboxylic acid · (-)-(S)-Proline · (-)-2-Pyrrolidinecarboxylic acid · (S)-2-Carboxypyrrolidine
Show all 19 names
(S)-2-Pyrrolidinecarboxylic acid · (S)-Pyrrolidine-2-carboxylic acid · 2-Pyrrolidine carboxylic acid · 2-Pyrrolidinecarboxylic acid, (S)- · Cb 1707 · Carboxypyrrolidine · L-Pro · L-Prolin · L-alpha-Pyrrolidinecarboxylic acid · PRO (IUPAC abbreviation) · pro · prolina · Prolinum
What it does: Used in cosmetics as a skin-conditioning agent and a hair conditioner.
Skin conditioning
Hair conditioning
Flavouring agent
Fragrance
Flavouring
Conditioner
Is it a concern?: High concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 368 composition records across product categories including Laboratory supplies, Personal care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Proline appears in these published regulatory listings.

In marketed US drugs
Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Industrial

EUEFSAEFSA opinion2 entries
- Scientific Opinion on the safety and efficacy of the use of amino acids (chemical group 34) when used as flavourings for all animal species (EFSA FEEDAP)Source →
- Flavouring Group Evaluation 79, (FGE.79). Consideration of amino acids and related substances evaluated by JECFA (63rd meeting) structurally related to amino acids from chemical group 34 evaluated by EFSA in FGE.26Rev1 (2008). Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)Source →
USFDAinactive ingredient database2 entries
- Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Potency: 0.34 %w/vSource →
- Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 0.8 %w/vSource →
EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
GLOBALJECFANo safety concern at current levels of intake when used as a flavouring agentJECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.
- JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 368 composition records across product categories including Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Anti-static agent, Softener and conditioner, Fragrance.
- EPA CPDat observed this chemical in 368 composition records across product categories including Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Anti-static agent, Softener and conditioner, Fragrance.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 59 active drug products and 59 total products.
- FDA NDC lists this ingredient in 59 active drug products and 59 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
- Scientific Opinion on the safety and efficacy of the use of amino acids (chemical group 34) when used as flavourings for all animal species (EFSA FEEDAP)
  2014 · EU EFSA listing · Read the source →
- Flavouring Group Evaluation 79, (FGE.79). Consideration of amino acids and related substances evaluated by JECFA (63rd meeting) structurally related to amino acids from chemical group 34 evaluated by EFSA in FGE.26Rev1 (2008). Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)
  2008 · EU EFSA listing · Read the source →
JECFA
Joint FAO/WHO Expert Committee on Food Additives
- JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.
  Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Proline yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

10 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated September 2018
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
WHO JECFA Database
regulatory · updated 2026-10-04
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Proline in a product composition. These are source records, not Greenveil catalog products.

Source records

368

Named organisations

Laboratory suppliesPersonal care

Typical roles

Skin conditioningHair conditioningFlavouring agentFragranceFlavouringConditioner

See products using Proline →

Catalog

Found in these products

Their ingredient lists include Proline; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 168 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Proline in the catalog.