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Methylcobalamin

CAS 35-09-6 · 40/100 · High conf.

Also registered as 7 other CAS numbers

13870-88-7 · 15417-95-5 · 15550-62-6 · 19709-17-2 · 23319-80-4 · 133191-56-7 · 13422-55-4

Methylcobalamin chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Methylcobalamin in plain language

What it is

Also known as Mecobalamin · Mecobalamine · Mecobalamin (USAN:INN:BAN:JAN) · Methyl B12 · Methyl vitamin B12 · METHYL-5,6-DIMETHYLBENZIMIDAZOLYLCOBALAMIN

Show all 21 names

Adestolmin · Algobaz · Co-Methylcobalamin · Cobaday · Cobalamin, Co-methyl- · Cobalt-methylcobalamin · Cobamet · Cobametin · Hitocobamin M · Mbl-a · Methycobal · Mecobalamina · Mecobalaminum · UNII-BR1SN1JS2W · Vancomin

What it does

Used in cosmetics as a skin-conditioning agent.

  • Skin conditioning
Is it a concern?
Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Methylcobalamin appears in these published regulatory listings.

  • In marketed US drugs

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUCosIngActiveMethylcobalamin is the organic compound that conforms to the formula.
    • Methylcobalamin is the organic compound that conforms to the formula.Source →
  • EUEFSAEFSA opinionScientific opinion on 5'-deoxyadenosylcobalamin and methylcobalamin as sources for Vitamin B12 added as a nutritional substance in food supplements (EFSA ANS)
    • Scientific opinion on 5'-deoxyadenosylcobalamin and methylcobalamin as sources for Vitamin B12 added as a nutritional substance in food supplements (EFSA ANS)Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 33 active drug products and 36 total products.
    • FDA NDC lists this ingredient in 33 active drug products and 36 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Scientific opinion on 5'-deoxyadenosylcobalamin and methylcobalamin as sources for Vitamin B12 added as a nutritional substance in food supplements (EFSA ANS)

      2008 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Methylcobalamin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated 30 November 2009

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2029-05-28

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Methylcobalamin in a product composition. These are source records, not Greenveil catalog products.

Source records

36

Typical roles

Skin conditioning
See products using Methylcobalamin →

Catalog

Found in these products

Their ingredient lists include Methylcobalamin; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 175 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Methylcobalamin in the catalog.