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Dipropylene glycol

CAS 25322-23-0 · 80/100 · High conf.

Also registered as 8 other CAS numbers

27941-90-8 · 27941-91-9 · 28678-26-4 · 30370-61-7 · 75047-14-2 · 78644-49-2 · 110-98-5 · 25265-71-8

Concern score

80/100Critical concern based on regulatory listings.
High confidence

Dipropylene glycol in plain language

What it is

Also known as Oxybispropanol · 1,1'-Oxydipropan-1-ol · Adk dpg-rf · Caswell No. 399E · Dipropyleneglycol · Dipropylenglykol

Show all 10 names

Dowanol DPG · Oxydipropanol · Propanol, oxybis- · oxidipropanol

What it does

Used in cosmetics as a solvent, a thickener and a fragrance ingredient.

  • Solvent
  • Viscosity controlling
  • Perfuming
  • Fragrance
  • Carrier solvent
  • Thickener
Is it a concern?
Critical concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 3303 composition records across product categories including Construction and building materials, Furniture and furnishings, Raw materials.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Dipropylene glycol appears in these published regulatory listings.

  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Industrial
  • USFDAinactive ingredient database3 entries — 2 administration routes
    • Route: TRANSDERMAL; Dosage form: FILM, EXTENDED RELEASE; Maximum daily exposure: 296 mgSource →
    • Route: BUCCAL; Dosage form: FILM, EXTENDED RELEASE; Maximum daily exposure: 30 mgSource →
    • Route: TRANSDERMAL; Dosage form: SYSTEM; Maximum daily exposure: 6 mgSource →
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • GLOBALJECFANO ADI ALLOCATEDJECFA evaluation lists ADI NO ADI ALLOCATED. Functional class: carrier solvent.
    • JECFA evaluation lists ADI NO ADI ALLOCATED. Functional class: carrier solvent.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 3303 composition records across product categories including Construction and building materials, Furniture and furnishings, Raw materials. EPA CPDat classifies this chemical for functional uses including Solvent, Solubility enhancer, Fragrance.
    • EPA CPDat observed this chemical in 3303 composition records across product categories including Construction and building materials, Furniture and furnishings, Raw materials. EPA CPDat classifies this chemical for functional uses including Solvent, Solubility enhancer, Fragrance.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as mixture.
    • openFDA substance registry classifies this ingredient as mixture.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    • JECFA evaluation lists ADI NO ADI ALLOCATED. Functional class: carrier solvent.

      Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Dipropylene glycol yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated september 5, 2012

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • WHO JECFA Database

    regulatory · updated 2026-10-04

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →
Reference links (1)
Openfda substance

pesticideinfo.org

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Dipropylene glycol in a product composition. These are source records, not Greenveil catalog products.

Source records

3,303

Named organisations

6

Construction and building materialsFurniture and furnishingsRaw materialsHome maintenanceLaboratory suppliesCleaning products and household care

Typical roles

SolventViscosity controllingPerfumingFragranceCarrier solventThickener
See products using Dipropylene glycol →

Catalog

Found in these products

Their ingredient lists include Dipropylene glycol; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 448 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Dipropylene glycol in the catalog.