- beauty
- cleaning
- food
- industrial
Edetate disodium
CAS 6381-92-6
Also registered as 2 other CAS numbers
1149703-65-0 · 2585661-76-1
Concern score
Not assessed — no hazard data yet.
Edetate disodium in plain language
Also known as Disodium edetate · Disodium EDTA · Disodium edetate hydrate · Disodium edetate dihydrate · Disodium ethylenediaminetetraacetate dihydrate · (ethylenedinitrilo) tetraacetic acid disodium salt dihydrate
Show all 35 names
Disodium EDTA dihydrate · E-386 · EDTA disodium · EDTA disodium salt · Ins NO.386 · INS-386 · Chelest f-na · Disodium (ethylenedinitrilo)tetraacetate dihydrate · Disodium - EDTA · Disodium ethylenediaminetetraacetate · Dissolvine NA2-P · Edeta bd · Edetate disodium dihydrate · EDTA disodium salt dihydrate · EDTA, disodium salt, dihydrate, crystal · Endrate · Ethylenediaminetetraacetic acid disodium dihydrate · Edetate disodium (USP) · Ethylenediaminetetraacetic acid disoium salt dihydrate · Na2H2EDTA.2H2O · Sodium versenate · Titriplex iii · UNII-7FLD91C86K · Versene na · Versene NA2 crystals · disodium dihydrogen ethylenediaminetetraacetate dihydrate · disodium dihydrogen ethylenediaminetetraacetatedihydrate · disodium dihydrogen ethylenediaminetetracetatedihydrate · edta disodium dihydrate
Used in consumer products as an antioxidant, a chelating agent and a fragrance ingredient.
- Antioxidant
- Chelating agent
- Fragrance
- Flavouring
- We haven't assessed a concern score for this ingredient yet.
Regulation
No restrictions found. Edetate disodium appears in these published regulatory listings.
- In marketed US drugs
- Inactive ingredient in US drugs
- Found in consumer products
- Beauty
- Cleaning
- Pharma
- Food
- Industrial
USFDAinactive ingredient database74 entries — 20 administration routes
- Route: AURICULAR (OTIC); Dosage form: SOLUTION; Potency: 0.1 %w/vSource →
- Route: AURICULAR (OTIC); Dosage form: SUSPENSION; Potency: 0.01 %w/vSource →
- Route: AURICULAR (OTIC); Dosage form: SUSPENSION/ DROPS; Potency: 0.01 %w/vSource →
- Route: INFILTRATION; Dosage form: INJECTION; Maximum daily exposure: 6 mgSource →
- Route: INTRA-ARTICULAR; Dosage form: INJECTION; Potency: 0.05 %w/vSource →
- Route: INTRABURSAL; Dosage form: INJECTION; Potency: 0.01 %w/vSource →
- Route: INTRACARDIAC; Dosage form: INJECTION; Maximum daily exposure: 2 mgSource →
- Route: INTRALESIONAL; Dosage form: INJECTION; Potency: 0.05 %w/vSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION; Potency: 10 %w/vSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 4 mgSource →
- Route: INTRAVASCULAR; Dosage form: INJECTION; Potency: 0.48 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 10 %w/vSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, EMULSION; Maximum daily exposure: 59 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, FOR SOLUTION; Maximum daily exposure: 6 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, FOR SUSPENSION; Potency: 0.4 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Maximum daily exposure: 19 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 7 mgSource →
- Route: INTRAVENOUS; Dosage form: LIQUID; Potency: 0.03 %w/vSource →
- Route: INTRAVENOUS; Dosage form: SOLUTION; Potency: 0.05 %w/vSource →
- Route: IONTOPHORESIS; Dosage form: SYSTEM; Potency: 0.1 mgSource →
- Route: NASAL; Dosage form: DROPS; Potency: 0.1 mg/1mlSource →
- Route: NASAL; Dosage form: LIQUID; Potency: 2 mg/1mlSource →
- Route: NASAL; Dosage form: SOLUTION; Potency: 100 mg/100mlSource →
- Route: NASAL; Dosage form: SPRAY; Maximum daily exposure: 1 mgSource →
- Route: NASAL; Dosage form: SPRAY, METERED; Maximum daily exposure: 4 mgSource →
- Route: OPHTHALMIC; Dosage form: DROPS; Potency: 0.05 %w/vSource →
- Route: OPHTHALMIC; Dosage form: EMULSION; Potency: 0.3 %w/vSource →
- Route: OPHTHALMIC; Dosage form: GEL; Maximum daily exposure: 396 mgSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION; Maximum daily exposure: 4 mgSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION/ DROPS; Potency: 0.13 %w/vSource →
- Route: OPHTHALMIC; Dosage form: SUSPENSION; Potency: 0.06 %w/vSource →
- Route: OPHTHALMIC; Dosage form: SUSPENSION/ DROPS; Maximum daily exposure: 1 mgSource →
- Route: ORAL; Dosage form: CAPSULE; Maximum daily exposure: 5 mgSource →
- Route: ORAL; Dosage form: CONCENTRATE; Maximum daily exposure: 20 mgSource →
- Route: ORAL; Dosage form: ELIXIR; Potency: 1.3 mg/5mlSource →
- Route: ORAL; Dosage form: LIQUID; Potency: 0.5 mg/1mlSource →
- Route: ORAL; Dosage form: POWDER, FOR SUSPENSION; Maximum daily exposure: 285 mgSource →
- Route: ORAL; Dosage form: SOLUTION; Maximum daily exposure: 432 mgSource →
- Route: ORAL; Dosage form: SUSPENSION; Maximum daily exposure: 30 mgSource →
- Route: ORAL; Dosage form: SUSPENSION, EXTENDED RELEASE; Maximum daily exposure: 40 mgSource →
- + 34 more entries not shown
GLOBALJECFAEvaluatedJECFA evaluation record.
- JECFA evaluation record.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 171 composition records across product categories including Laboratory supplies, Food and drug, Pet and animal care. EPA CPDat classifies this chemical for functional uses including Fragrance, Antioxidant, Chelating agent.
- EPA CPDat observed this chemical in 171 composition records across product categories including Laboratory supplies, Food and drug, Pet and animal care. EPA CPDat classifies this chemical for functional uses including Fragrance, Antioxidant, Chelating agent.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 2 active drug products and 2 total products.
- FDA NDC lists this ingredient in 2 active drug products and 2 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Expert safety opinions
Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
JECFA
Joint FAO/WHO Expert Committee on Food Additives
JECFA evaluation record.
Year not recorded · GLOBAL JECFA listing · Read the source →
EFSA
European Food Safety Authority
No EFSA opinion on file.
Evidence & sources
No graded research studies for Edetate disodium yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
EPA Chemical and Products Database
exposure · updated october 24, 2019
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
- Open →
FDA National Drug Code Directory
regulatory · updated 2026-12-31
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
WHO JECFA Database
regulatory · updated 2026-10-04
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Food use
Nothing to weigh for this context yet.
We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.
Fragrance avoidance
Not a strong fit for fragrance avoidance because it carries Fragrance.
The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.
Where it has been recorded
How often EPA CPDat has listed Edetate disodium in a product composition. These are source records, not Greenveil catalog products.
Source records
171
Named organisations
6
Laboratory suppliesFood and drugPet and animal carePersonal care
Typical roles
AntioxidantChelating agentFragranceFlavouring
Found in these products
Their ingredient lists include Edetate disodium; each product's own rating depends on its whole formula, so it is shown on the product page, not here.
- CeraVe Schuimende ReinigingsgelCeraVe · Beauty
- Foaming cleanserL'Oréal,Cerave · Non Food Products
- CeraVe Hydraterende ReinigingscrèmeCerave · Beauty
- Blemish control cleanserCerave,L'Oréal
- CeraVe Hydraterende ReinigingscrèmeCeraVe · Face
- Gel 92 % Aloe veraBetty's nature · Gel Corps
- CeraVe Hydraterende MelkCeraVe · Beauty
- NottregonaNeutrogena · Open Beauty Facts
- JohnsonsJohnsons · Baby Shampoo
- Lipikar Baume AP+ MLa Roche-Posay,loreal · Body
- CeraVe Hydraterende CrèmeBeauty
- ToallitasDodot
- Beauty of Joseon, Relief Sun: Rice + Probiotics, SPF 50+ PA ++++Beauty of Joseon · Beauty
- ShampooDeliplus, Mercadona · Open Beauty Facts
- Chargement…Non Food Products
- sun protection
- Vichy normadem phytosolutionVichy
- Dove Advanced Care Original Antitranspirant RollerDove · Hygiene
- Toallitas bebé frescas y perfumadasDeliplus · Accessories
- Coconut MilkHerbal Essences · Hair
- Phytamine Gel nettoyantPhytamine, Phytamine gel nettyant
- Kids spray solaireCien Sun · Open Beauty Facts
- BiodermaBioderma
- VaselineOpen Beauty Facts
Often appears with
Ingredients that frequently appear alongside Edetate disodium in the catalog.