What does Edetate disodium anhydrous do?

Used in cosmetics as a chelating agent and a thickener.

Is Edetate disodium anhydrous safe?

Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

beauty
cleaning
food
industrial

Edetate disodium anhydrous

CAS 139-33-3 · 40/100 · High conf.

Also registered as 6 other CAS numbers

1892-64-4 · 37341-71-2 · 42615-28-1 · 69772-70-9 · 104244-09-9 · 1236140-51-4

Edetate disodium anhydrous chemical structure

Concern score

40/100Moderate concern based on regulatory listings.

High confidence

Edetate disodium anhydrous in plain language

What it is: On cosmetic ingredient lists it appears as “Disodium EDTA”.
Also known as Disodium EDTA · EDTA disodium salt anhydrous · Edetate disodium · E.D.T.A. disodique · Disodium ethylenediaminetetraacetate · EDTA disodium salt
Show all 32 names
disodium salt Ethylenediaminetetraacetic acid · Anhydrous disodium edetate · Disodium salt edetic acid · Aethylendiamin-tetraessigsaeure-di-na-salz · Chelaplex · Chelaplex III · Chelaton III · Chelest 200 · Chelest 2BS · Disodium (ethylenedinitrilo)tetraacetate · Disodium dihydrogen ethylenediaminetetraacetate · Disodium edathamil · anhydrous Disodium edta · Anhydrous edetate disodium · EDTA disodium salt (anhydrous) · EDTA-Na2 · Edta disodium · Endrate (TN) · Endrate disodium · F 1 (van) · Na2-EDTA · Tetracemate disodium · Titriplex III · disodium ethylene diaminetetraacete · ethylenediamine tetraacetic acid disodium salt · natrii edetas
What it does: Used in cosmetics as a chelating agent and a thickener.
Chelating
Viscosity controlling
Antioxidant synergist, preservative, sequestrant, synergist
Antioxidant
Preservative
Surfactant
Is it a concern?: Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 13174 composition records across product categories including Food and drug, Specialty occupational products, Laboratory supplies.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Edetate disodium anhydrous appears in these published regulatory listings.

Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Pharma
Food
Industrial

USFDAinactive ingredient database5 entries — 5 administration routes
- Route: ORAL; Dosage form: SOLUTION; Potency: 0.5 mgSource →
- Route: TOPICAL; Dosage form: CREAM; Potency: 0.02 %w/wSource →
- Route: VAGINAL; Dosage form: CREAM; Potency: 0.05 %w/wSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION; Potency: 0.01 %w/vSource →
- Route: INTRAVENOUS; Dosage form: INJECTION; Maximum daily exposure: 3 mgSource →
EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
GLOBALJECFA0-2.5 mg/kg bwJECFA evaluation lists ADI 0-2.5 mg/kg bw. Functional class: antioxidant synergist, preservative, sequestrant, synergist.
- JECFA evaluation lists ADI 0-2.5 mg/kg bw. Functional class: antioxidant synergist, preservative, sequestrant, synergist.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 13174 composition records across product categories including Food and drug, Specialty occupational products, Laboratory supplies. EPA CPDat classifies this chemical for functional uses including Chelating agent, Viscosity modifier, Biocide.
- EPA CPDat observed this chemical in 13174 composition records across product categories including Food and drug, Specialty occupational products, Laboratory supplies. EPA CPDat classifies this chemical for functional uses including Chelating agent, Viscosity modifier, Biocide.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
JECFA
Joint FAO/WHO Expert Committee on Food Additives
- JECFA evaluation lists ADI 0-2.5 mg/kg bw. Functional class: antioxidant synergist, preservative, sequestrant, synergist.
  Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Edetate disodium anhydrous yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EPA Chemical and Products Database
exposure · updated september 9, 2014
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
WHO JECFA Database
regulatory · updated 2026-10-02
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Edetate disodium anhydrous in a product composition. These are source records, not Greenveil catalog products.

Source records

13,174

Named organisations

Food and drugSpecialty occupational productsLaboratory suppliesPersonal careIndustrial productsCleaning and safety

Typical roles

ChelatingViscosity controllingAntioxidant synergist, preservative, sequestrant, synergistAntioxidantPreservativeSurfactant

See products using Edetate disodium anhydrous →

Catalog

Found in these products

Cosmetic and personal-care products that list Edetate disodium anhydrous are shown first. Their ingredient lists include Edetate disodium anhydrous; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Edetate disodium anhydrous in the catalog.