What does Chlorphenesin do?

Used in cosmetics as a preservative and an antimicrobial.

Is Chlorphenesin safe?

Minor concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

beauty
cleaning
food
pharma

Chlorphenesin

CAS 104-29-0 · 20/100 · High conf.

Also registered as 2 other CAS numbers

62067-20-3 · 2320573-12-2

Concern score

20/100Minor concern based on regulatory listings.

High confidence

Chlorphenesin in plain language

What it is: Also known as Clorfenesina · 3-(p-Chlorophenoxy)-propane-1,2-diol · 3-(4-Chlorophenoxy)propane-1,2-diol · (.+-.)-Chlorphenesin · (.+-.)-p-Chlorphenesin · 1,2-Propanediol, 3-(4-chlorophenoxy)-
Show all 18 names
1,2-Propanediol, 3-(p-chlorophenoxy)- · 2-Chlorphenesin · 3-(4-CHLOROPHENOXY)-1,2-PROPANEDIOL · 3-(p-Chlorophenoxy)-1,2-propanediol · Chlorphenesine · Chlorphenesinum · Demykon · Gecophen · Glycerol alpha-p-chlorophenyl ether · chlorophenesin · p-Chlorophenyl glyceryl ether · p-Chlorophenyl-alpha-glyceryl ether
What it does: Used in cosmetics as a preservative and an antimicrobial.
Preservative
Antimicrobial
Is it a concern?: Minor concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

What the listings say

Permitted, with conditions — Chlorphenesin appears on published "allowed" regulatory lists rather than on a restriction list.

3-(p-Chlorophenoxy)-propane-1,2-diol is listed in Annex V of the EU Cosmetics Regulation (EC) 1223/2009 (preservatives allowed in cosmetic products).

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Chlorphenesin appears in these published regulatory listings.

EU Annex V — permitted preservative
EU permitted preservative
In marketed US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Pharma
Food

EUCosIngActive2 entries
- Cosmetics Regulation annex V / ref 50.Source →
- Chlorphenesin is the organic compound that conforms to the formula: Restriction: V/50Source →
EUECallowed_listedAnnex V of EU Cosmetics Regulation (EC) 1223/2009: preservatives allowed in cosmetic products. Maximum concentration: 0.3%
- Annex V of EU Cosmetics Regulation (EC) 1223/2009: preservatives allowed in cosmetic products. Maximum concentration: 0.3%Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 2337 composition records across product categories including Personal care, Batteries, Food and drug. EPA CPDat classifies this chemical for functional uses including Biocide, Preservative.
- EPA CPDat observed this chemical in 2337 composition records across product categories including Personal care, Batteries, Food and drug. EPA CPDat classifies this chemical for functional uses including Biocide, Preservative.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 2 drug products and 2 package presentations.
- FDA NDC lists this ingredient in 2 drug products and 2 package presentations.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Chlorphenesin. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.

Evidence & sources

No graded research studies for Chlorphenesin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2010-10-16
Open →
EPA Chemical and Products Database
exposure · updated october 24, 2019
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA National Drug Code Directory
regulatory · updated 2028-03-09
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Chlorphenesin in a product composition. These are source records, not Greenveil catalog products.

Source records

2,337

Named organisations

Personal careBatteriesFood and drugHome maintenance

Typical roles

PreservativeAntimicrobial

See products using Chlorphenesin →

Catalog

Found in these products

Their ingredient lists include Chlorphenesin; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 430 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Chlorphenesin in the catalog.