- beauty
- cleaning
- food
- pharma
Thiamine hydrochloride
CAS 63-66-1 · 60/100 · High conf.
Also registered as 5 other CAS numbers
70732-86-4 · 108631-50-1 · 2173536-98-4 · 2227489-38-3 · 67-03-8
Concern score
60/100High concern based on regulatory listings.
High confidence
Thiamine hydrochloride in plain language
On cosmetic ingredient lists it appears as “Thiamine hcl”.
Also known as Thiamine hcl · Thiamine chloride hydrochloride · Hydrochloride thiamine chloride · Thymine hydrochloride · Vitamin B1 · Aneurine hydrochloride
Show all 31 names
Vitamin B1 hydrochloride · Clotiamina · Eskaphen · Apate drops · Betalin s · Betamin · Beatine · Begiolan · Benerva · Betabion hydrochloride · Bevitine · Biamine · Thiamin chloride · Thiamin dichloride · Thiamine dichloride · monohydrochloride Thiamine · Thiaminium chloride hydrochloride · Vitamin b(sub 1) hydrochloride · thiamin hydrochloride · thiamine hydrochloride (b1) · thiamine hydrochloride (vitamin b1) · thiamine hydrochloride - 200 mg/vial · thiamine hydrochloride. einecs # 200-641-8. · Thiaminum hydrochloricum · thiamini hydrochloridum
Used in cosmetics as a skin-conditioning agent and a fragrance ingredient.
- Skin conditioning
- Fragrance
- Flavouring agent
- Flavouring
- Conditioner
- Deodorant
- High concern: no hazard classifications on record. It is listed for cosmetic use in the EU.
Why it's flagged
EPA CPDat observed this chemical in 66 composition records across product categories including Food and drug, Personal care.
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Regulation
No restrictions found. Thiamine hydrochloride appears in these published regulatory listings.
- In marketed US drugs
- Found in consumer products
- Beauty
- Cleaning
- Pharma
- Food
EUEFSAEFSA opinion6 entries
- Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) (EFSA CEF)Source →
- Safety and efficacy of thiazoles, thiophene and thiazoline belonging to chemical group 29 when used as flavourings for all animal species (EFSA FEEDAP)Source →
- Scientific Opinion on the safety and efficacy of vitamin B1 (thiamine mononitrate and thiamine hydrochloride) as a feed additive for all animal species based on a dossier submitted by Lohmann Animal Health (EFSA FEEDAP)Source →
- Scientific Opinion on the safety and efficacy of vitamin B1 (thiamine mononitrate and thiamine hydrochloride) as a feed additive for all animal species based on a dossier submitted by DSM Nutritional Products (EFSA FEEDAP)Source →
- Flavouring Group Evaluation 76, (FGE.76): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21. Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)Source →
- Benfotiamine, thiamine monophosphate chloride and thiamine pyrophosphate chloride, as sources of vitamin B1 added for nutritional purposes to food supplements (EFSA ANS)Source →
EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
GLOBALJECFANo safety concern at current levels of intake when used as a flavouring agentJECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.
- JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.Source →
GLOBALJECFAEvaluatedJECFA evaluation record.
- JECFA evaluation record.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 66 composition records across product categories including Food and drug, Personal care. EPA CPDat classifies this chemical for functional uses including Deodorizer, Softener and conditioner, Fragrance.
- EPA CPDat observed this chemical in 66 composition records across product categories including Food and drug, Personal care. EPA CPDat classifies this chemical for functional uses including Deodorizer, Softener and conditioner, Fragrance.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Expert safety opinions
Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) (EFSA CEF)
2013 · EU EFSA listing · Read the source →
Safety and efficacy of thiazoles, thiophene and thiazoline belonging to chemical group 29 when used as flavourings for all animal species (EFSA FEEDAP)
2016 · EU EFSA listing · Read the source →
Scientific Opinion on the safety and efficacy of vitamin B1 (thiamine mononitrate and thiamine hydrochloride) as a feed additive for all animal species based on a dossier submitted by Lohmann Animal Health (EFSA FEEDAP)
2011 · EU EFSA listing · Read the source →
Scientific Opinion on the safety and efficacy of vitamin B1 (thiamine mononitrate and thiamine hydrochloride) as a feed additive for all animal species based on a dossier submitted by DSM Nutritional Products (EFSA FEEDAP)
2011 · EU EFSA listing · Read the source →
Flavouring Group Evaluation 76, (FGE.76): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21. Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)
2008 · EU EFSA listing · Read the source →
Benfotiamine, thiamine monophosphate chloride and thiamine pyrophosphate chloride, as sources of vitamin B1 added for nutritional purposes to food supplements (EFSA ANS)
2008 · EU EFSA listing · Read the source →
JECFA
Joint FAO/WHO Expert Committee on Food Additives
JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.
Year not recorded · GLOBAL JECFA listing · Read the source →
JECFA evaluation record.
Year not recorded · GLOBAL JECFA listing · Read the source →
Evidence & sources
No graded research studies for Thiamine hydrochloride yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
CosIng
regulatory · updated 2026-09-23
- Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
- Open →
EPA Chemical and Products Database
exposure · updated September 2018
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA National Drug Code Directory
regulatory · updated 2026-12-31
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
WHO JECFA Database
regulatory · updated 2026-10-04
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Reference links (1)
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Food use
Food-use source coverage is present in the current record.
The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.
Fragrance avoidance
Not a strong fit for fragrance avoidance because it carries Fragrance.
The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.
Where it has been recorded
How often EPA CPDat has listed Thiamine hydrochloride in a product composition. These are source records, not Greenveil catalog products.
Source records
66
Named organisations
6
Food and drugPersonal care
Typical roles
Skin conditioningFragranceFlavouring agentFlavouringConditionerDeodorant
Found in these products
Their ingredient lists include Thiamine hydrochloride; each product's own rating depends on its whole formula, so it is shown on the product page, not here.
- Cuetara Digesta Light 200G Marie CookiesCuétara · Snacks
- Magnesio + Vitaminas B1 B6 B12 sabor NaranjaDeliplus · Dietary Supplements
- All Bran Budskellogs · Plant Based Foods And Beverages
- Barritas con proteínas sabor coco y chocolateEnervit Sport · Snacks
- Nutritional YeastBragg · Condiments
- All-Bran BudsKellogg's · Plant Based Foods And Beverages
- Chocolate Protein Shakepremier protein · Batidos De Proteínas
- Magnesium BrausetablettenVitalis · Beverages And Beverages Preparations
- Kellogg's All-Bran Original impKellogg’s · Plant Based Foods And Beverages
- VectorKellogg's · Plant Based Foods And Beverages
- Rice Krispies Treats OriginalKellogg's · Snacks
- VECTORKellogg's · Plant Based Foods And Beverages
- Fortimel extraNutricia
- Chicken NuggetsImpossible · Meats And Their Products
- MultivitaminOrange, altapharma · Beverages And Beverages Preparations
- CerealKellogg's · Plant Based Foods And Beverages
- All-Bran BudsKellogg's · Plant Based Foods And Beverages
- Whole Grain CerealWeetabix · Plant Based Foods And Beverages
- Original nutrition shakeEnsure · Plant Based Foods And Beverages
- MultivitaminVitalis · Beverages And Beverages Preparations
- Serious MassOPTIMUM NUTRITION · Dietary Supplements
- Galletas de sésamoGerblé,Nutrition & Sante · Snacks
- Corn FlakesKellogg's · Plant Based Foods And Beverages
- Berocca EnergieBayer · Dietary Supplements
Often appears with
Ingredients that frequently appear alongside Thiamine hydrochloride in the catalog.