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Citric acid monohydrate

E330 · CAS 5949-29-1 · 0/100 · High conf.

Also registered as 2 other CAS numbers

15686-65-4 · 2579498-77-2

Citric acid monohydrate chemical structure

Concern score

0/100Low concern — well-established and permitted without restriction (FDA GRAS; JECFA ADI not specified; CIR safe as used; EU food additive).
High confidence

Citric acid monohydrate in plain language

What it is

Also known as Citric acid · Citrate · Hydrous citric acid · Citric acid hydrate · 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) · 2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)

Show all 31 names

1,2,3-PROPANETRICARBOXYLIC acid, 2 hydroxy-, monohydrate · 2-HYDROXY-1,2,3-PROPANE-TRICARBOXYLIC acid, monohydrate · 2-Hydroxypropane-1,2,3-tricarboxylic acid--water (1/1) · 2-hydroxypropane-1,2,3-tricarboxylic acid;hydrate · Citric acid bp · 2-HYDROXY-1,2,3-PROPANE-TRICARBOXYLIC acid · 2-Hydroxy-1,2,3-propanetricarboxylic acid, Monohydrate · AQUACETIC-30 · Alphacide Activator · CITRACID-50 · Citiric acid · E-330 · Green fresh · Ins NO.330 · INS-330 · Nature clean · Purilab · Soothe Chewable · Stop Hair · Surface Wipes · W.skin treemon cleansing water · citric acid. (h3c6h5o7.h2o) · Taurolock component citrate · Acidum citricum monohydrate · Cleaning Solution for Hemodialysis Machines

What it does

Used in consumer products as a pH adjuster.

  • pH adjuster
Is it a concern?
Low concern: no hazard classifications on record.

As a food additive

E-number
E330
Used in food as
  • Acidity regulator
  • Acidifier
  • Antioxidant synergist
EU safety status

Authorised in the EU without a numerical limit (Group I); EFSA re-evaluation not yet published.

It never counts as an additive of concern in a product’s food rating.

Regulation (EC) No 1333/2008, Annex II Part C(1) Group I (quantum satis)

Why it's flagged

EPA CPDat observed this chemical in 60 composition records across product categories including Laboratory supplies, Food and drug, Raw materials.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Citric acid monohydrate appears in these published regulatory listings.

  • In marketed US drugs
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • Industrial
  • USFDAinactive ingredient database89 entries — 29 administration routes
    • Route: AURICULAR (OTIC); Dosage form: SOLUTION; Potency: 0.2 %w/vSource →
    • Route: AURICULAR (OTIC); Dosage form: SOLUTION/ DROPS; Potency: 0.04 %w/wSource →
    • Route: BUCCAL; Dosage form: SOLUTION; Potency: NASource →
    • Route: EPIDURAL; Dosage form: INJECTION; Potency: 0.02 %w/vSource →
    • Route: INFILTRATION; Dosage form: INJECTION; Potency: 0.02 %w/vSource →
    • Route: INTRA-ARTICULAR; Dosage form: INJECTION; Potency: ADJ PHSource →
    • Route: INTRA-ARTICULAR; Dosage form: INJECTION, SOLUTION; Potency: ADJ PHSource →
    • Route: INTRABURSAL; Dosage form: INJECTION; Potency: ADJ PHSource →
    • Route: INTRACARDIAC; Dosage form: INJECTION; Potency: 1.05 %w/vSource →
    • Route: INTRALESIONAL; Dosage form: INJECTION; Potency: ADJ PHSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION; Maximum daily exposure: 28 mgSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION, POWDER, FOR SOLUTION; Potency: NASource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 26 mgSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION, SUSPENSION, EXTENDED RELEASE; Maximum daily exposure: 38 mgSource →
    • Route: INTRAMUSCULAR; Dosage form: SOLUTION; Potency: 0.05 %w/vSource →
    • Route: INTRAOCULAR; Dosage form: INJECTION, SOLUTION, CONCENTRATE; Potency: 0.24 mg/5mlSource →
    • Route: INTRAOCULAR; Dosage form: SOLUTION; Maximum daily exposure: 1 mgSource →
    • Route: INTRAPLEURAL; Dosage form: INJECTION; Potency: ADJ PHSource →
    • Route: INTRASYNOVIAL; Dosage form: INJECTION; Potency: ADJ PHSource →
    • Route: INTRATHECAL; Dosage form: INJECTION; Potency: ADJ PHSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 2068 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, FOR SOLUTION; Maximum daily exposure: 608 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Maximum daily exposure: 385 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 396 mgSource →
    • Route: INTRAVENOUS; Dosage form: LIQUID; Potency: 0.2 %w/vSource →
    • Route: INTRAVENOUS; Dosage form: SOLUTION; Maximum daily exposure: 10 mgSource →
    • Route: INTRAVENOUS; Dosage form: SOLUTION, CONCENTRATE; Potency: NASource →
    • Route: IONTOPHORESIS; Dosage form: SOLUTION; Potency: 0.02 %w/vSource →
    • Route: IONTOPHORESIS; Dosage form: SYSTEM; Potency: 0.2 mgSource →
    • Route: IRRIGATION; Dosage form: INJECTION, SOLUTION, CONCENTRATE; Potency: 0.03 %w/vSource →
    • Route: NASAL; Dosage form: SOLUTION; Potency: 2.8 mg/1mlSource →
    • Route: NASAL; Dosage form: SPRAY; Maximum daily exposure: 9 mgSource →
    • Route: NASAL; Dosage form: SPRAY, METERED; Maximum daily exposure: 2 mgSource →
    • Route: OPHTHALMIC; Dosage form: SOLUTION; Potency: 0.03 %w/vSource →
    • Route: OPHTHALMIC; Dosage form: SOLUTION/ DROPS; Potency: 0.05 %w/vSource →
    • Route: OPHTHALMIC; Dosage form: SUSPENSION; Potency: ADJ PHSource →
    • Route: ORAL; Dosage form: CAPSULE; Maximum daily exposure: 238 mgSource →
    • Route: ORAL; Dosage form: CAPSULE, EXTENDED RELEASE; Maximum daily exposure: 101 mgSource →
    • Route: ORAL; Dosage form: CONCENTRATE; Potency: 5.3 mg/1mlSource →
    • Route: ORAL; Dosage form: DROPS; Potency: NASource →
    • + 49 more entries not shown
  • USFDAmarketed drug occurrence2 entries
    • FDA NDC lists this ingredient in 1 active drug products and 1 total products.Source →
    • FDA NDC lists this ingredient in 50 active drug products and 51 total products.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 60 composition records across product categories including Laboratory supplies, Food and drug, Raw materials. EPA CPDat classifies this chemical for functional uses including pH regulating agent, Processing aids not otherwise specified.
    • EPA CPDat observed this chemical in 60 composition records across product categories including Laboratory supplies, Food and drug, Raw materials. EPA CPDat classifies this chemical for functional uses including pH regulating agent, Processing aids not otherwise specified.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Citric acid monohydrate. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    No JECFA evaluation on file.

  • EFSA

    European Food Safety Authority

    No EFSA opinion on file.

Evidence & sources

No graded research studies for Citric acid monohydrate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • EPA Chemical and Products Database

    exposure · updated November 2014

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (3)
Openfda substance

codexalimentarius.net

Read →
Openfda substance

sciencestuff.com

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Citric acid monohydrate in a product composition. These are source records, not Greenveil catalog products.

Source records

60

Named organisations

6

Laboratory suppliesFood and drugRaw materialsPersonal careCleaning products and household care

Typical roles

pH adjuster
See products using Citric acid monohydrate →

Catalog

Found in these products

Their ingredient lists include Citric acid monohydrate; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Citric acid monohydrate in the catalog.