- beauty
- cleaning
- food
- industrial
Glycerin
CAS 11003-00-2 · 40/100 · High conf.
Also registered as 16 other CAS numbers
26403-55-4 · 62180-90-9 · 101662-08-2 · 107283-02-3 · 144086-03-3 · 153050-05-6 · 8013-25-0 · 29796-42-7 · 30049-52-6 · 37228-54-9 · 75398-78-6 · 78630-16-7 · 1400594-62-8 · 1422250-43-8 · 1629856-20-7 · 56-81-5
Concern score
40/100Moderate concern based on regulatory listings.
High confidence
Glycerin in plain language
Also known as Glycerol · Anhydrous glycerin · Glycerol 85% · Glycerine · E 422 · E422
Show all 36 names
Propane-1,2,3-triol · Tryhydroxypropane · 1,2,3-Trihydroxypropane · 2-Propanol, 1,3-dihydroxy- · Dagralax · E-422 · Crude glycerine · Glyceritol · Glycyl alcohol · Glyrol · Glysanin · Grocolene · Ins NO.422 · INS-422 · Kosher Vegetable Glycerin · M 314429 · Moon · Ophthalgan · Optim · Osmoglyn · Pzn 7474853 · Synthetic glycerin · Synthetic glycerine · Trihydroxypropane · Vitrosupos · additives · glycerin (glycerol) · Glycerinum · Monoctanoin component d · glycerolum
Used in cosmetics as a humectant, a solvent and a hair conditioner. Glycerin is the polyhydric alcohol.
- Humectant
- Solvent
- Hair conditioning
- Oral care
- Skin protecting
- Viscosity controlling
- Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.
Why it's flagged
EPA CPDat observed this chemical in 35327 composition records across product categories including Personal care, Cleaning products and household care, Construction and building materials.
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Regulation
No restrictions found. Glycerin appears in these published regulatory listings.
- In marketed US drugs
- Inactive ingredient in US drugs
- Found in consumer products
- Beauty
- Cleaning
- Pharma
- Food
- Industrial
USFDAinactive ingredient database75 entries — 17 administration routes
- Route: DENTAL; Dosage form: PASTE; Potency: 20 %w/wSource →
- Route: DENTAL; Dosage form: PASTE, DENTIFRICE; Potency: 18 %w/wSource →
- Route: DENTAL; Dosage form: SOLUTION; Potency: 15 %w/vSource →
- Route: INTRADERMAL; Dosage form: INJECTION; Potency: 1.6 %w/vSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION; Maximum daily exposure: 450 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION, SOLUTION; Potency: 15 %w/vSource →
- Route: INTRAVENOUS; Dosage form: EMULSION; Potency: 2.2 %w/vSource →
- Route: INTRAVENOUS; Dosage form: INJECTION; Maximum daily exposure: 550 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, EMULSION; Maximum daily exposure: 24100 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Potency: 225 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Potency: 15 %w/vSource →
- Route: IONTOPHORESIS; Dosage form: SYSTEM; Potency: 168.1 mgSource →
- Route: NASAL; Dosage form: DROPS; Potency: 10 mg/1mlSource →
- Route: NASAL; Dosage form: SOLUTION; Potency: 25 mg/1mlSource →
- Route: NASAL; Dosage form: SPRAY; Potency: 22.3 mg/1mlSource →
- Route: NASAL; Dosage form: SPRAY, METERED; Maximum daily exposure: 13 mgSource →
- Route: OPHTHALMIC; Dosage form: EMULSION; Maximum daily exposure: 3 mgSource →
- Route: OPHTHALMIC; Dosage form: GEL; Potency: 0.88 %w/wSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION; Potency: 6 %w/vSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION/ DROPS; Maximum daily exposure: 12 mgSource →
- Route: OPHTHALMIC; Dosage form: SUSPENSION; Maximum daily exposure: 58 mgSource →
- Route: OPHTHALMIC; Dosage form: SUSPENSION/ DROPS; Potency: 2.5 %w/vSource →
- Route: ORAL; Dosage form: CAPSULE; Maximum daily exposure: 3487 mgSource →
- Route: ORAL; Dosage form: CAPSULE, COATED; Potency: 14.21 mgSource →
- Route: ORAL; Dosage form: CAPSULE, EXTENDED RELEASE; Maximum daily exposure: 265 mgSource →
- Route: ORAL; Dosage form: CAPSULE, LIQUID FILLED; Maximum daily exposure: 185 mgSource →
- Route: ORAL; Dosage form: CONCENTRATE; Maximum daily exposure: 1800 mgSource →
- Route: ORAL; Dosage form: DROPS; Potency: 300 mg/1mlSource →
- Route: ORAL; Dosage form: ELIXIR; Potency: 500 mg/1mlSource →
- Route: ORAL; Dosage form: LIQUID; Maximum daily exposure: 2400 mgSource →
- Route: ORAL; Dosage form: PASTE; Maximum daily exposure: 3822 mgSource →
- Route: ORAL; Dosage form: SOLUTION; Maximum daily exposure: 32400 mgSource →
- Route: ORAL; Dosage form: SOLUTION, CONCENTRATE; Potency: 200 mg/1mlSource →
- Route: ORAL; Dosage form: SUSPENSION; Maximum daily exposure: 26208 mgSource →
- Route: ORAL; Dosage form: SUSPENSION, EXTENDED RELEASE; Maximum daily exposure: 2000 mgSource →
- Route: ORAL; Dosage form: SUSPENSION/ DROPS; Maximum daily exposure: 750 mgSource →
- Route: ORAL; Dosage form: SYRUP; Maximum daily exposure: 16734 mgSource →
- Route: ORAL; Dosage form: TABLET; Maximum daily exposure: 42 mgSource →
- Route: ORAL; Dosage form: TABLET, CHEWABLE; Maximum daily exposure: 12 mgSource →
- Route: ORAL; Dosage form: TABLET, COATED; Potency: 1 mgSource →
- + 35 more entries not shown
EUEFSAEFSA opinion3 entries
- Re-evaluation of glycerol (E 422) as a food additive (EFSA ANS)Source →
- Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part III of III (EFSA CONTAM)Source →
- Follow-up of the re-evaluation of glycerol (E 422) as a food additive (EFSA FAF)Source →
EUCosIngActiveGlycerin is the polyhydric alcohol that conforms generally to the formula
- Glycerin is the polyhydric alcohol that conforms generally to the formulaSource →
GLOBALJECFANOT SPECIFIED (1976)JECFA evaluation lists ADI NOT SPECIFIED (1976). Functional class: thickener, flavouring agent, carrier solvent, emulsifier, humectant.
- JECFA evaluation lists ADI NOT SPECIFIED (1976). Functional class: thickener, flavouring agent, carrier solvent, emulsifier, humectant.Source →
GLOBALJECFAEvaluatedJECFA evaluation record.
- JECFA evaluation record.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 35327 composition records across product categories including Personal care, Cleaning products and household care, Construction and building materials. EPA CPDat classifies this chemical for functional uses including Solvent, Emulsifier, Humectant.
- EPA CPDat observed this chemical in 35327 composition records across product categories including Personal care, Cleaning products and household care, Construction and building materials. EPA CPDat classifies this chemical for functional uses including Solvent, Emulsifier, Humectant.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 316 active drug products and 339 total products.
- FDA NDC lists this ingredient in 316 active drug products and 339 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Expert safety opinions
Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
Re-evaluation of glycerol (E 422) as a food additive (EFSA ANS)
2017 · EU EFSA listing · Read the source →
Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part III of III (EFSA CONTAM)
2012 · EU EFSA listing · Read the source →
Follow-up of the re-evaluation of glycerol (E 422) as a food additive (EFSA FAF)
2022 · EU EFSA listing · Read the source →
JECFA
Joint FAO/WHO Expert Committee on Food Additives
JECFA evaluation lists ADI NOT SPECIFIED (1976). Functional class: thickener, flavouring agent, carrier solvent, emulsifier, humectant.
Year not recorded · GLOBAL JECFA listing · Read the source →
JECFA evaluation record.
Year not recorded · GLOBAL JECFA listing · Read the source →
Evidence & sources
No graded research studies for Glycerin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
CosIng
regulatory · updated 2026-09-23
- Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
- Open →
EPA Chemical and Products Database
exposure · updated september 9, 2014
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
- Open →
FDA National Drug Code Directory
regulatory · updated 2029-08-02
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
WHO JECFA Database
regulatory · updated 2026-10-04
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PMC Open Access
literature · updated 2026-03-12
- Open →
PubChem
chemistry · updated 2026-01-15
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Reference links (2)
Follow-up of the re-evaluation of glycerol (E 422) as a food additive.
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Food use
Food-use source coverage is present in the current record.
The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.
Fragrance avoidance
Not a strong fit for fragrance avoidance because it carries Fragrance.
The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.
Where it has been recorded
How often EPA CPDat has listed Glycerin in a product composition. These are source records, not Greenveil catalog products.
Source records
35,327
Named organisations
6
Personal careCleaning products and household careConstruction and building materialsOther indirect contact consumer goodsHome maintenanceFood and drug
Typical roles
HumectantSolventHair conditioningOral careSkin protectingViscosity controlling
Found in these products
Their ingredient lists include Glycerin; each product's own rating depends on its whole formula, so it is shown on the product page, not here.
- Crema ManosS'nonas · Creams
- DOVE Déodorant Femme Anti-Transpirant Stick Original 50mlunilever, dove · Deodorants Anti Transpirants
- moisturising creamCeraVe · Baume Hydratant
- True Dent DentrifriceNon Food Products
- 68YN5T 400mlUltra doux · Non Food Products
- Lait de toilette très douxMixa,Mixa Bébé · Bebe
- CeraVe Schuimende ReinigingsgelCeraVe · Beauty
- GlysolidNon Food Products
- Foaming cleanserL'Oréal,Cerave · Non Food Products
- KalosKalos · Dairies
- Nivea softNivéa · Cosmetic Products
- Coconut MilkHerbal Essences · Health Beauty
- CeraVe Hydraterende ReinigingscrèmeCerave · Beauty
- MatinaSnacks
- idéal soleilVichy · Non Food Products
- garnierGarnier
- Cream pure urea 10%Deliplus · Body
- CeraVe Hydraterende ReinigingscrèmeCeraVe · Face
- Ultra DouxL'Oréal,L'Oreal Consumer products,Garnier
- Gel 92 % Aloe veraBetty's nature · Gel Corps
- DeodorantDeliplus · Open Beauty Facts
- CeraVe Hydraterende MelkCeraVe · Beauty
- JohnsonsJohnsons · Baby Shampoo
- Cicaplast Baume B5+La Roche Posay · Baumes Et Beurres Pour Le Corps
Often appears with
Ingredients that frequently appear alongside Glycerin in the catalog.