food
pharma

Carboxymethylcellulose sodium

CAS 9004-32-4 · 0/100 · High conf.

Concern score

0/100Low concern — well-established and permitted without restriction (FDA GRAS; JECFA ADI not specified; CIR safe as used; EU food additive; EU CosIng).

High confidence

Carboxymethylcellulose sodium in plain language

What it is: Also known as Carmellose sodium · Cellulose gum · Unspecified carboxymethylcellulose sodium · Cmc · Sodium cellulose glycolate · Sodium cmc
Show all 15 names
Unspecified form carboxymethylcellulose sodium · Denvercel ph 2008A · E-466 · Ins NO.466 · INS-466 · Sodium carboxymethyl cellulose · Sodium carboxymethylcellulose · E 466 · E 468
What it does: We don't have a plain-language description for Carboxymethylcellulose sodium yet.
Is it a concern?: Low concern: no hazard classifications on record.

Why it's flagged

Route: BUCCAL; Dosage form: FILM; Maximum daily exposure: 18 mg

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Carboxymethylcellulose sodium appears in these published regulatory listings.

In marketed US drugs
Inactive ingredient in US drugs

USFDAinactive ingredient database45 entries — 13 administration routes
- Route: BUCCAL; Dosage form: FILM, SOLUBLE; Maximum daily exposure: 47 mgSource →
- Route: BUCCAL; Dosage form: TABLET; Potency: 4 mgSource →
- Route: DENTAL; Dosage form: GEL; Potency: 0.4 %w/wSource →
- Route: DENTAL; Dosage form: PASTE; Maximum daily exposure: 249 mgSource →
- Route: DENTAL; Dosage form: PASTE, DENTIFRICE; Potency: 1.2 %w/wSource →
- Route: ENTERAL; Dosage form: SUSPENSION; Maximum daily exposure: 2920 mgSource →
- Route: INTRA-ARTICULAR; Dosage form: INJECTION; Maximum daily exposure: 25 mgSource →
- Route: INTRA-ARTICULAR; Dosage form: INJECTION, POWDER, FOR SUSPENSION; Maximum daily exposure: 25 mgSource →
- Route: INTRA-ARTICULAR; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 30 mgSource →
- Route: INTRALESIONAL; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 15 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION; Maximum daily exposure: 30 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION, POWDER, FOR SUSPENSION; Maximum daily exposure: 25 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Maximum daily exposure: 5 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 30 mgSource →
- Route: INTRAMUSCULAR; Dosage form: POWDER, FOR SUSPENSION; Potency: 0.7 %w/vSource →
- Route: INTRASYNOVIAL; Dosage form: INJECTION; Potency: 0.1 %w/vSource →
- Route: INTRAVITREAL; Dosage form: INJECTION, SUSPENSION; Potency: 0.5 %w/vSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION; Maximum daily exposure: 1 mgSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION/ DROPS; Maximum daily exposure: 2 mgSource →
- Route: ORAL; Dosage form: CAPSULE; Potency: 160 mgSource →
- Route: ORAL; Dosage form: CAPSULE, DELAYED RELEASE; Potency: 4.2 mgSource →
- Route: ORAL; Dosage form: CAPSULE, EXTENDED RELEASE; Maximum daily exposure: 4 mgSource →
- Route: ORAL; Dosage form: GRANULE; Potency: NASource →
- Route: ORAL; Dosage form: GRANULE, FOR SUSPENSION; Potency: 15.63 mg/5mlSource →
- Route: ORAL; Dosage form: POWDER, FOR SOLUTION; Maximum daily exposure: 161 mgSource →
- Route: ORAL; Dosage form: POWDER, FOR SUSPENSION; Maximum daily exposure: 560 mgSource →
- Route: ORAL; Dosage form: SOLUTION; Maximum daily exposure: 3480 mgSource →
- Route: ORAL; Dosage form: SUSPENSION; Maximum daily exposure: 1600 mgSource →
- Route: ORAL; Dosage form: SUSPENSION/ DROPS; Potency: 12.85 mg/2.5mlSource →
- Route: ORAL; Dosage form: SYRUP; Potency: 26.5 mgSource →
- Route: ORAL; Dosage form: TABLET; Maximum daily exposure: 280 mgSource →
- Route: ORAL; Dosage form: TABLET, CHEWABLE; Potency: 24.75 mgSource →
- Route: ORAL; Dosage form: TABLET, COATED; Potency: 3.2 mgSource →
- Route: ORAL; Dosage form: TABLET, DELAYED RELEASE; Maximum daily exposure: 280 mgSource →
- Route: ORAL; Dosage form: TABLET, EXTENDED RELEASE; Maximum daily exposure: 933 mgSource →
- Route: ORAL; Dosage form: TABLET, FILM COATED; Potency: 50 mgSource →
- Route: ORAL; Dosage form: TABLET, FILM COATED, EXTENDED RELEASE; Maximum daily exposure: 100 mgSource →
- Route: SOFT TISSUE; Dosage form: INJECTION; Potency: 0.75 %w/vSource →
- Route: SOFT TISSUE; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 15 mgSource →
- Route: TOPICAL; Dosage form: LOTION; Potency: NASource →
- + 5 more entries not shown
GLOBALJECFAEvaluatedJECFA evaluation record.
- JECFA evaluation record.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 67 active drug products and 67 total products.
- FDA NDC lists this ingredient in 67 active drug products and 67 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as mixture.
- openFDA substance registry classifies this ingredient as mixture.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

JECFA
Joint FAO/WHO Expert Committee on Food Additives
- JECFA evaluation record.
  Year not recorded · GLOBAL JECFA listing · Read the source →
EFSA
European Food Safety Authority
No EFSA opinion on file.

Evidence & sources

No graded research studies for Carboxymethylcellulose sodium yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

5 data sources

Where this comes from

FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
WHO JECFA Database
regulatory · updated 2026-10-04
Open →
openFDA Substance
registry · updated 2026-05-24
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Carboxymethylcellulose sodium in a product composition. These are source records, not Greenveil catalog products.

Source records

See products using Carboxymethylcellulose sodium →

Catalog

Found in these products

Their ingredient lists include Carboxymethylcellulose sodium; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Carboxymethylcellulose sodium in the catalog.