beauty
cleaning
food
industrial

Hydroxyacetophenone

CAS 261172-42-3 · 60/100 · High conf.

Also registered as 1 other CAS number

99-93-4

Concern score

60/100High concern based on regulatory listings.

High confidence

Hydroxyacetophenone in plain language

What it is: Also known as 4-HYDROXYACETOPHENONE · 4'-Hydroxyacetophenone · 1-(4-Hydroxyphenyl)ethan-1-one · 1-(4-hydroxyphenyl)ethanone · 4-HYDROXY acetophenone · P-hydroxyacetophenone
Show all 22 names
P-hydroxyphenyl methyl ketone · (4-Hydroxyphenyl)ethan-1-one · 1-(4-Hydroxyphenyl)-1-ethanone · 4'-HYDROXY acetophenone · 4'-Hydroxyacetophenon · 4'-Hydroxyacetophenone (Ethanone, 1-(4-hydroxyphenyl)-) · 4'-hidroxiacetofenona · 4-Acetophenol · 4-Acetylphenol · Ethanone, 1-(4-hydroxyphenyl)- · Ethanone, 1-(4-hydroxyphenyl)-,p-Hydroxyacetophenone · Para hydroxyacetophenone · Methyl p-hydroxyphenyl ketone · Piceol · hydroxyacteophenone · para-Hydroxyacetophenone
What it does: Used in cosmetics as an antioxidant.
Antioxidant
Flavouring agent
Preservative
Fragrance
Flavouring
Is it a concern?: High concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 15 composition records across product categories including Raw materials, Laboratory supplies, Personal care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Hydroxyacetophenone appears in these published regulatory listings.

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Industrial

EUEFSAEFSA opinion2 entries
- Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25 (EFSA CEF)Source →
- Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 22: Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) (EFSA AFC)Source →
EUCosIngActiveHydroxyacetophenone is the organic compound
- Hydroxyacetophenone is the organic compoundSource →
GLOBALJECFANo safety concern at current levels of intake when used as a flavouring agentJECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.
- JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 15 composition records across product categories including Raw materials, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Antioxidant, Flavouring and nutrient, Fragrance.
- EPA CPDat observed this chemical in 15 composition records across product categories including Raw materials, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Antioxidant, Flavouring and nutrient, Fragrance.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
- Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25 (EFSA CEF)
  2011 · EU EFSA listing · Read the source →
- Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 22: Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) (EFSA AFC)
  2007 · EU EFSA listing · Read the source →
JECFA
Joint FAO/WHO Expert Committee on Food Additives
- JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.
  Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Hydroxyacetophenone yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated may 15, 2015
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
WHO JECFA Database
regulatory · updated 2026-10-04
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (1)

Openfda substance

chemicalbook.com

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Hydroxyacetophenone in a product composition. These are source records, not Greenveil catalog products.

Source records

Named organisations

Raw materialsLaboratory suppliesPersonal care

Typical roles

AntioxidantFlavouring agentPreservativeFragranceFlavouring

See products using Hydroxyacetophenone →

Catalog

Found in these products

Their ingredient lists include Hydroxyacetophenone; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 444 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Hydroxyacetophenone in the catalog.