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POLYGLYCERIN-40

CAS 64333-26-2 · 40/100 · High conf.

Also registered as 9 other CAS numbers

70926-61-3 · 175385-78-1 · 280575-69-1 · 1206185-99-0 · 1206186-81-3 · 1312543-37-5 · 2143496-79-9 · 25618-55-7 · 59113-36-9

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

POLYGLYCERIN-40 in plain language

What it is

On cosmetic ingredient lists it appears as “Diglycerin”.

Also known as Diglycerin · POLYGLYCERIN-20 · Polyglycerol · Polyglycerin 20P · 1,2,3-Propanetriol homopolymer · 1,​2,​3-​Propanetriol, homopolymer

Show all 15 names

Glycerin homopolymer · Glycerol homopolymer · Glycerol homopolymerise · Glycerol polymer · polymers Glycerol · Oxybispropanediol · Polyglycerin xp · Polyglycerine · Polyoxypropylene triol

What it does

Used in cosmetics as an antimicrobial, a humectant and a skin-conditioning agent. Diglycerin is a dimer of Glycerin.

  • Antimicrobial
  • Humectant
  • Skin conditioning
  • Conditioner
Is it a concern?
Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. POLYGLYCERIN-40 appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUCosIngActive3 entries
  • EUEFSAEFSA opinionScientific Opinion on the safety assessment of the substance, polyglycerol, CAS No 25618-55-7, for use in food contact materials (EFSA CEF)
    • Scientific Opinion on the safety assessment of the substance, polyglycerol, CAS No 25618-55-7, for use in food contact materials (EFSA CEF)Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Humectant, Biocide, Processing aids not otherwise specified.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Humectant, Biocide, Processing aids not otherwise specified.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as polymer.
    • openFDA substance registry classifies this ingredient as polymer.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Scientific Opinion on the safety assessment of the substance, polyglycerol, CAS No 25618-55-7, for use in food contact materials (EFSA CEF)

      2013 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for POLYGLYCERIN-40 yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

6 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated January 7, 2008

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed POLYGLYCERIN-40 in a product composition. These are source records, not Greenveil catalog products.

Named organisations

3

Typical roles

AntimicrobialHumectantSkin conditioningConditioner
See products using POLYGLYCERIN-40 →

Catalog

Found in these products

Their ingredient lists include POLYGLYCERIN-40; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 51 →Find products without it →