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Sodium bisulfate

CAS 12262-56-5 · 40/100 · High conf.

Also registered as 2 other CAS numbers

1903778-63-1 · 7681-38-1

Sodium bisulfate chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Sodium bisulfate in plain language

What it is

Also known as Sodium hydrogen sulfate · Sodium sulfate · Sodium bisulphate · Nitre cake · Sodium acid sulfate · Acid sodium sulfate

Show all 30 names

Bisulfate of soda · E-514(II) · Hydrogenosulfate de sodium · Ins NO.514(II) · INS-514(II) · Monobasic sodium sulfate · Monosodium hydrogen sulfate · Monosodium sulfate · Niter cake · fused Sodium bisulfate · Sodium bisulfate, solid(DOT) · Sodium hydrogen sulfate (NaHSO4) · Sodium hydrogen sulfate, solid (DOT) · Sodium hydrogensulphate · Sodium hydrosulfate · Sodium sulfate, NaHSO4 · monosodium salt Sulfuric acid · WC-Klosettreiniger · WC-Perfect · WC-Super · hidrogenosulfato de sodio · sodium bisulfate (cas #7681-38-1) · sodium busulfate · sodium hydrogen sulfate/sodium bisulfate

What it does

Used in cosmetics as a pH buffer.

  • Buffering
  • Acid
  • pH adjuster
  • Antimicrobial
Is it a concern?
Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 169 composition records across product categories including Specialty occupational products, Laboratory supplies, Personal care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Sodium bisulfate appears in these published regulatory listings.

  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • Industrial
  • USFDAinactive ingredient database6 entries — 6 administration routes
    • Route: RESPIRATORY (INHALATION); Dosage form: SOLUTION; Potency: 0.01 %w/wSource →
    • Route: SUBCUTANEOUS; Dosage form: INJECTION; Potency: 0.1 %w/vSource →
    • Route: ORAL; Dosage form: CONCENTRATE; Potency: 0.95 mg/1mlSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 0.32 %w/vSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION; Potency: 0.32 %w/vSource →
    • Route: OPHTHALMIC; Dosage form: SUSPENSION/ DROPS; Potency: 0.06 %w/vSource →
  • EUEFSAEFSA opinion3 entries
    • Re-evaluation of sulphuric acid and its sodium, potassium, calcium and ammonium salts (E 513, 514 (i), 514 (ii), 515 (i), 515 (ii), 516 and 517) as food additive (EFSA FAF)Source →
    • Scientific Opinion on the safety and efficacy of sodium bisulphate (SBS) for all animal species as preservative and silage additive, for pets and other non food-producing animals (non-food fur animals) as acidity regulator and for pets as flavouring (EFSA FEEDAP)Source →
    • Scientific Opinion on the safety and efficacy of sodium bisulphate (SBS) for all species as preservative and silage additive (EFSA FEEDAP)Source →
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • GLOBALJECFAEvaluatedJECFA evaluation record. Functional class: acid.
    • JECFA evaluation record. Functional class: acid.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 169 composition records across product categories including Specialty occupational products, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including pH regulating agent, Processing aids not otherwise specified, Biocide.
    • EPA CPDat observed this chemical in 169 composition records across product categories including Specialty occupational products, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including pH regulating agent, Processing aids not otherwise specified, Biocide.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Re-evaluation of sulphuric acid and its sodium, potassium, calcium and ammonium salts (E 513, 514 (i), 514 (ii), 515 (i), 515 (ii), 516 and 517) as food additive (EFSA FAF)

      2019 · EU EFSA listing · Read the source →

    • Scientific Opinion on the safety and efficacy of sodium bisulphate (SBS) for all animal species as preservative and silage additive, for pets and other non food-producing animals (non-food fur animals) as acidity regulator and for pets as flavouring (EFSA FEEDAP)

      2011 · EU EFSA listing · Read the source →

    • Scientific Opinion on the safety and efficacy of sodium bisulphate (SBS) for all species as preservative and silage additive (EFSA FEEDAP)

      2014 · EU EFSA listing · Read the source →

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    • JECFA evaluation record. Functional class: acid.

      Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Sodium bisulfate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated September 2013

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • WHO JECFA Database

    regulatory · updated 2026-10-04

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (2)
Openfda substance

codexalimentarius.net

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Sodium bisulfate in a product composition. These are source records, not Greenveil catalog products.

Source records

169

Named organisations

6

Specialty occupational productsLaboratory suppliesPersonal careRaw materialsFood and drugCleaning products and household care

Typical roles

BufferingAcidpH adjusterAntimicrobial
See products using Sodium bisulfate →

Catalog

Found in these products

Their ingredient lists include Sodium bisulfate; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 204 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Sodium bisulfate in the catalog.