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Manganese gluconate

CAS 12261-90-4 · 0/100 · High conf.

Also registered as 2 other CAS numbers

84368-35-4 · 6485-39-8

Manganese gluconate chemical structure

Concern score

0/100Low concern — well-established and permitted without restriction (FDA GRAS; EU CosIng).
High confidence

Manganese gluconate in plain language

What it is

Also known as Manganese gluconate anhydrous · Manganese(2+) dihexonate · D-gluconic acid, manganese salt (2:1) · Gluconic acid, manganese salt (2:1) · Manganese (ii) d-gluconate · Manganese d-gluconate (1:2)

Show all 19 names

Manganese gluconate (anhydrous) · Manganese, BIS(D-GLUCONATO-.KAPPA.O1,.KAPPA.O2)-, (T-4)- · Manganese, BIS(D-GLUCONATO-O1,O2)-, (T-4)- · Manganese(2+) di(D-gluconate) · Bis(D-gluconato-O1,O2)manganese · C12H22MnO14 · D-Gluconic acid, manganese(2+) salt (2:1) · Unspecified manganese gluconate · Manganese D-gluconate · Manganese(II) gluconate · Manganese, bis(D-gluconato-kO1,kO2)-, (T-4)- · manganese(2+);(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate · Manganese (as manganese gluconate)

What it does

Used in cosmetics as a skin-conditioning agent.

  • Skin conditioning
  • Flavouring
  • Conditioner
  • Antimicrobial
Is it a concern?
Low concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 40 composition records across product categories including Personal care, Food and drug.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Manganese gluconate appears in these published regulatory listings.

  • In marketed US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 40 composition records across product categories including Personal care, Food and drug. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, No specific technical function, Mineral.
    • EPA CPDat observed this chemical in 40 composition records across product categories including Personal care, Food and drug. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, No specific technical function, Mineral.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 22 active drug products and 26 total products.
    • FDA NDC lists this ingredient in 22 active drug products and 26 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Manganese gluconate. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Manganese gluconate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated September 2013

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2029-04-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Manganese gluconate in a product composition. These are source records, not Greenveil catalog products.

Source records

40

Named organisations

6

Personal careFood and drug

Typical roles

Skin conditioningFlavouringConditionerAntimicrobial
See products using Manganese gluconate →

Catalog

Found in these products

Their ingredient lists include Manganese gluconate; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 215 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Manganese gluconate in the catalog.