beauty
cleaning
food

Disodium 5'-INOSINATE

CAS 14999-51-0 · 40/100 · High conf.

Also registered as 5 other CAS numbers

6757-07-9 · 133749-71-0 · 398516-04-6 · 131-99-7 · 4691-65-0

Disodium 5'-INOSINATE chemical structure

Concern score

40/100Moderate concern based on regulatory listings.

High confidence

Disodium 5'-INOSINATE in plain language

What it is: On cosmetic ingredient lists it appears as “Disodium inosinate”.
Also known as Disodium inosinate · Inosine monophosphate disodium · C10H11N4Na2O8P · Sodium 5'-INOSINATE · 5'-INOSINIC acid, disodium salt · 5'-INOSINIC acid, sodium salt (1:2)
Show all 23 names
Disodium 5'-O-phosphonatoinosine · E 631 (food enhancement agent) · Imp disodium salt · Inosine 5'-MONOPHOSPHATE disodium salt hydrate · Sodium inosinate · 5'-Imp disodium salt · 5'-Inosinic acid, disodium · Disodium 5-inosinate · Disodium inosine 5'-monophosphate · Disodium inosine 5'-phosphate · E 631 · F429809 · Inosine 5'-MONOPHOSPHATE disodium · Inosine 5'-MONOPHOSPHORIC acid disodium salt · Ins NO.631 · INS-631 · Inosine 5'-disodium phosphate
What it does: Used in cosmetics as a humectant, an emollient and a skin-conditioning agent.
Humectant
Emollient
Skin conditioning
Flavour enhancer
Thickener
Fragrance
Is it a concern?: Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 3 composition records across product categories including Personal care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Disodium 5'-INOSINATE appears in these published regulatory listings.

Recorded in these product areas

Found in consumer products
Beauty
Cleaning

EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
EUEFSAEFSA opinionScientific Opinion on the safety and efficacy of disodium 5'-ribonucleotides, disodium 5'-guanylate, disodium 5'-inosinate for all animal species and categories (EFSA FEEDAP)
- Scientific Opinion on the safety and efficacy of disodium 5'-ribonucleotides, disodium 5'-guanylate, disodium 5'-inosinate for all animal species and categories (EFSA FEEDAP)Source →
GLOBALJECFANOT SPECIFIEDJECFA evaluation lists ADI NOT SPECIFIED. Functional class: flavour enhancer.
- JECFA evaluation lists ADI NOT SPECIFIED. Functional class: flavour enhancer.Source →
GLOBALJECFAEvaluatedJECFA evaluation record.
- JECFA evaluation record.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 3 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, Fragrance.
- EPA CPDat observed this chemical in 3 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, Fragrance.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
- Scientific Opinion on the safety and efficacy of disodium 5'-ribonucleotides, disodium 5'-guanylate, disodium 5'-inosinate for all animal species and categories (EFSA FEEDAP)
  2014 · EU EFSA listing · Read the source →
JECFA
Joint FAO/WHO Expert Committee on Food Additives
- JECFA evaluation lists ADI NOT SPECIFIED. Functional class: flavour enhancer.
  Year not recorded · GLOBAL JECFA listing · Read the source →
- JECFA evaluation record.
  Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Disodium 5'-INOSINATE yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated July 2013
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
WHO JECFA Database
regulatory · updated 2026-10-04
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (2)

Openfda substance

fao.org

Read →

Openfda substance

codexalimentarius.net

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Disodium 5'-INOSINATE in a product composition. These are source records, not Greenveil catalog products.

Source records

Named organisations

Personal care

Typical roles

HumectantEmollientSkin conditioningFlavour enhancerThickenerFragrance

See products using Disodium 5'-INOSINATE →

Catalog

Found in these products

Their ingredient lists include Disodium 5'-INOSINATE; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 75 →Find products without it →