Food use
Food-use source coverage is present in the current record.
The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.
- beauty
- food
- industrial
- pharma
Valine
CAS 7004-03-7 · 60/100 · High conf.
Also registered as 6 other CAS numbers
16872-32-5 · 154605-70-6 · 1613375-16-8 · 72-18-4 · 516-06-3 · 640-68-6
Concern score
60/100High concern based on regulatory listings.
High confidence
Valine in plain language
Also known as L-valine · (2S)-2-amino-3-methylbutanoic acid · Val · (2S)-2-amino-3-methylbutanoate · (S)-2-Amino-3-methylbutanoic acid · (S)-2-Amino-3-methylbutyric acid
Show all 21 names
(S)-Valine · (S)-alpha-Amino-beta-methylbutyric acid · 2-Amino-3-methylbutanoic acid · 2-Amino-3-methylbutyric acid · 2-amino-3-methylbutanoate · Butanoic acid, 2-amino-3-methyl-, (S)- · L-(+)-α-Aminoisovaleric acid · L-Val · L-Valine High · L-alpha-Amino-beta-methylbutyric acid · L-valin · Valine, L- · l-(+)-alpha-Aminoisovaleric acid · valina · valinum
Used in cosmetics as a skin-conditioning agent, a hair conditioner and an antistatic agent.
- Skin conditioning
- Hair conditioning
- Antistatic
- Fragrance
- Flavouring
- High concern: no hazard classifications on record. It is listed for cosmetic use in the EU.
Why it's flagged
EPA CPDat observed this chemical in 1 composition records across product categories including unclassified products.
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Regulation
No restrictions found. Valine appears in these published regulatory listings.
- In marketed US drugs
- Inactive ingredient in US drugs
- Found in consumer products
- Industrial
EUEFSAEFSA opinion8 entries
- Efficacy and safety of L-valine from a modified E.coli K12 for all animal species (EFSA FEEDAP, EFSA GMO)Source →
- Scientific Opinion on the safety and efficacy of the use of amino acids (chemical group 34) when used as flavourings for all animal species (EFSA FEEDAP)Source →
- Scientific Opinion on Flavouring Group Evaluation 401 (FGE.401): gamma-Glutamyl-valyl-glycine from chemical group 34 (EFSA CEF)Source →
- Scientific Opinion on the safety and efficacy of L-valine produced by Corynebacterium glutamicum (KCCM 80058) for all animal species (EFSA FEEDAP)Source →
- Safety of L-valine for all animal species (EFSA FEEDAP)Source →
- Amino acids from chemical group 34. Flavouring Group Evaluation 26, Revision 1. Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) (EFSA AFC)Source →
- Scientific Opinion on the safety and efficacy of L-valine (L-valine, feed grade) produced by Escherichia coli NITE BP-01755 for all animal species based on a dossier submitted by Ajinomoto Eurolysine S.A.S (EFSA FEEDAP)Source →
- Scientific Opinion on the safety and efficacy of L-valine (ValAMINO) produced by Corynebacterium glutamicum (DSM 25202) for all animal species, based on a dossier submitted by Evonik Industries AG (EFSA FEEDAP)Source →
EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 1 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including No specific technical function, Flavouring and nutrient, Fragrance.
- EPA CPDat observed this chemical in 1 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including No specific technical function, Flavouring and nutrient, Fragrance.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 67 active drug products and 68 total products.
- FDA NDC lists this ingredient in 67 active drug products and 68 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Expert safety opinions
Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
Efficacy and safety of L-valine from a modified E.coli K12 for all animal species (EFSA FEEDAP, EFSA GMO)
2008 · EU EFSA listing · Read the source →
Scientific Opinion on the safety and efficacy of the use of amino acids (chemical group 34) when used as flavourings for all animal species (EFSA FEEDAP)
2014 · EU EFSA listing · Read the source →
Scientific Opinion on Flavouring Group Evaluation 401 (FGE.401): gamma-Glutamyl-valyl-glycine from chemical group 34 (EFSA CEF)
2014 · EU EFSA listing · Read the source →
Scientific Opinion on the safety and efficacy of L-valine produced by Corynebacterium glutamicum (KCCM 80058) for all animal species (EFSA FEEDAP)
2013 · EU EFSA listing · Read the source →
Safety of L-valine for all animal species (EFSA FEEDAP)
2008 · EU EFSA listing · Read the source →
Amino acids from chemical group 34. Flavouring Group Evaluation 26, Revision 1. Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) (EFSA AFC)
2008 · EU EFSA listing · Read the source →
Scientific Opinion on the safety and efficacy of L-valine (L-valine, feed grade) produced by Escherichia coli NITE BP-01755 for all animal species based on a dossier submitted by Ajinomoto Eurolysine S.A.S (EFSA FEEDAP)
2015 · EU EFSA listing · Read the source →
Scientific Opinion on the safety and efficacy of L-valine (ValAMINO) produced by Corynebacterium glutamicum (DSM 25202) for all animal species, based on a dossier submitted by Evonik Industries AG (EFSA FEEDAP)
2014 · EU EFSA listing · Read the source →
Evidence & sources
No graded research studies for Valine yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
CosIng
regulatory · updated 2026-09-23
- Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
- Open →
EPA Chemical and Products Database
exposure · updated March 2000
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
- Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Good fit
Fragrance avoidance
Not a strong fit for fragrance avoidance because it carries Fragrance.
The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.
Where it has been recorded
How often FDA National Drug Code directory has listed Valine in a product composition. These are source records, not Greenveil catalog products.
Source records
68
Typical roles
Skin conditioningHair conditioningAntistaticFragranceFlavouring
Found in these products
Their ingredient lists include Valine; each product's own rating depends on its whole formula, so it is shown on the product page, not here.
- Hydrating cream-to-foam cleanserCeraVe · Face
- Beauty of Joseon Relief Sun Aqua Fresh SPF50+ ZonnebrandcrèmeBeauty
- The Ordinary Glycolic Acid 7% Toning Solution (Solução tonificante de ácido glicólico 7%)The Ordinary · Esfoliante
- ICE POP PRIME Hydration DrinkPRIME · Plant Based Foods And Beverages
- Strawberry BananaPRIME · Beverages And Beverages Preparations
- Protein OatsDoctor's Choice · Plant Based Foods And Beverages
- Lemonade Hydration DrinkPrime · Plant Based Foods And Beverages
- Meta Moon Hydration DrinkPrime · Beverages And Beverages Preparations
- Strawberry Watermelon Hydration DrinkPrime · Beverages And Beverages Preparations
- Fruit Punch Hydration DrinkPrime · Plant Based Foods And Beverages
- GlowberryPRIME · Beverages And Beverages Preparations
- prime hydration strawberry & bananaPRIME · Beverages And Beverages Preparations
- Prime - Blue ChillPrime · Beverages And Beverages Preparations
- Prime Hydration Drink - Lemon LimePrime Hydration · Beverages
- PRIME Meta MoonPRIME · Beverages And Beverages Preparations
- Cashew Nuts No SaltCoop · Plant Based Foods And Beverages
- 60% Protein BarWeider · Dietary Supplements
- Prime strawberry watermelonPRIME · Beverages
- Cherry Freeze HydrationPRIME · Beverages And Beverages Preparations
- REIGN Total Body Fuel White Gummy BearREIGN · Beverages And Beverages Preparations
- Pro V-Gain Advanced 100% Plant-Based High Protein BlendScimax Nutrition · Dietary Supplements
- Pro v-gain protein blend, vanilla flavourScimx nutrition · Dietary Supplements
- Star blast energy drinkBang Energy
- Red ChillPRIME
Often appears with
Ingredients that frequently appear alongside Valine in the catalog.