beauty
cleaning
industrial

Subtilisin

CAS 2392-42-9

Also registered as 14 other CAS numbers

9028-05-1 · 9031-73-6 · 9045-36-7 · 9063-47-2 · 9067-41-8 · 12626-20-9 · 12770-87-5 · 104645-85-4 · 148093-32-7 · 179530-31-5 · 196414-34-3 · 213972-06-6 · 1349805-21-5 · 9014-01-1

Concern score

Not assessed — no hazard data yet.

Subtilisin in plain language

What it is: Also known as Subtilisin a · Maxatase · Subtilisin bpn · Subtilisin bpn' · Subtilisin dfe · Subtilisin (Bacillus amyloliquefaciens)
Show all 19 names
Alcalase · Alcalase 0.6L · Alcalase 2.0M · Alcalase 2.4FG · Alcalase 2.4L · Alcalase 2.4L FG · Bacillussubtilis Alkaline proteinase · Novozym 80001 · Novozym fm · bacillus subtilis carlsberg · protease enzyme · subtilisins (bacillus subtilis carlsberg) · subtilisins (proteolytic enzymes)
What it does: Used in cosmetics as a skin-conditioning agent and a keratolytic.
Skin conditioning
Keratolytic
Conditioner
Cleaning agent
Is it a concern?: We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Subtilisin appears in these published regulatory listings.

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Industrial

EUCosIngActiveEnzymes, subtilisin
- Enzymes, subtilisinSource →
USEPAcommercial use observedEPA CPDat observed this chemical in 312 composition records across product categories including Cleaning and safety, Cleaning products and household care, Medical/dental. EPA CPDat classifies this chemical for functional uses including Cleaning agent, Chemical reaction regulator, Softener and conditioner.
- EPA CPDat observed this chemical in 312 composition records across product categories including Cleaning and safety, Cleaning products and household care, Medical/dental. EPA CPDat classifies this chemical for functional uses including Cleaning agent, Chemical reaction regulator, Softener and conditioner.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as protein.
- openFDA substance registry classifies this ingredient as protein.Source →

Expert safety opinions

No expert opinion on file for Subtilisin. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.

Evidence & sources

No graded research studies for Subtilisin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

5 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EPA Chemical and Products Database
exposure · updated march 13, 2018
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →

Reference links (1)

Openfda substance

uniprot.org

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often EPA CPDat has listed Subtilisin in a product composition. These are source records, not Greenveil catalog products.

Source records

312

Named organisations

Cleaning and safetyCleaning products and household careMedical/dentalPersonal care

Typical roles

Skin conditioningKeratolyticConditionerCleaning agent

See products using Subtilisin →

Catalog

Found in these products

Their ingredient lists include Subtilisin; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 41 →Find products without it →