beauty
cleaning
food
industrial

Allantoin

CAS 5377-33-3 · 0/100 · High conf.

Also registered as 3 other CAS numbers

37305-69-4 · 58308-55-7 · 97-59-6

Concern score

0/100Low concern — well-established and permitted without restriction (CIR safe as used; EU CosIng).

High confidence

Allantoin in plain language

What it is: Also known as Sd 101 · (2,5-dioxoimidazolidin-4-yl)urea · (±)-allantoin · Cordianine · Dl-allantoin · Idelalisib metabolite M1A
Show all 27 names
N-(2,5-Dioxoimidazolidin-4-yl)urea · Psoralon · Septalan · (.+-.)-Allantoin · (2,5-Dioxo-4-imidazolidinyl)urea · 4-ureido-2,5-Imidazolidinedione · 5-Ureidohydantoin · Alwextin · AVC/Dienestrolcream · Alantan · Allantol · Cutemol emollient · Glyoxyldiureid · Glyoxyldiureide · N-(2,5-Dioxo-4-imidazolidinyl)urea · Sebical · Uniderm A · Urea, (2,5-dioxo-4-imidazolidinyl)- · alantoina · allantoine · alloxantin
What it does: Used in cosmetics as a skin-conditioning agent, a skin protectant and a soothing agent.
Skin conditioning
Skin protecting
Soothing
Humectant
Fragrance
Conditioner
Is it a concern?: Low concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 3305 composition records across product categories including Cleaning and safety, Laboratory supplies, Personal care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Allantoin appears in these published regulatory listings.

In marketed US drugs
Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Pharma
Food
Industrial

EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 3305 composition records across product categories including Cleaning and safety, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Humectant, Fragrance.
- EPA CPDat observed this chemical in 3305 composition records across product categories including Cleaning and safety, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Humectant, Fragrance.Source →
USFDAinactive ingredient databaseRoute: TOPICAL; Dosage form: GEL; Maximum daily exposure: 8 mg
- Route: TOPICAL; Dosage form: GEL; Maximum daily exposure: 8 mgSource →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 120 active drug products and 127 total products.
- FDA NDC lists this ingredient in 120 active drug products and 127 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Allantoin. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.

Evidence & sources

No graded research studies for Allantoin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EPA Chemical and Products Database
exposure · updated september 17, 2016
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA National Drug Code Directory
regulatory · updated 2028-01-16
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (3)

Openfda substance

accessdata.fda.gov

Read →

Openfda substance

bioportfolio.com

Read →

Openfda substance

accessdata.fda.gov

Read →

Allergen profile

Canonical allergen markers detected on this ingredient. Each row is derived from the ingredient’s name or synonyms matching a known allergen class — useful when scanning a label for a specific allergy context.

DairyContains · Oral (ingested)
Source: chemindex_name_match

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Allantoin in a product composition. These are source records, not Greenveil catalog products.

Source records

3,305

Named organisations

Cleaning and safetyLaboratory suppliesPersonal careFood and drugRaw materialsPesticides

Typical roles

Skin conditioningSkin protectingSoothingHumectantFragranceConditioner

See products using Allantoin →

Catalog

Found in these products

Their ingredient lists include Allantoin; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 913 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Allantoin in the catalog.