What does Alfadex do?

Used in food as a thickener, adjuvant, carrier, stabilizer.

Moderate concern: no hazard classifications on record.

food
industrial
pharma

Alfadex

CAS 10016-20-3 · 40/100 · High conf.

Also registered as 8 other CAS numbers

23513-50-0 · 41871-62-9 · 47910-04-3 · 1229648-14-9 · 1244024-89-2 · 2095261-37-1 · 2592632-27-2 · 2923220-23-7

Concern score

40/100Moderate concern based on regulatory listings.

High confidence

Alfadex in plain language

What it is: Also known as .alpha.-cyclodextrin · Alpha cyclodextrin · Alpha-cyclodextrin · Cyclohexaamylose · Cyclomaltohexaose · alpha-DEXTRIN
Show all 26 names
alpha-SCHARDINGER DEXTRIN · Cavamax w 6 food · Celdex a 100 · Dexy pearl .ALPHA.-100 · E-457 · Ins NO.457 · INS-457 · Alfadexum · Alpha-Cyclodextrin (Cyclohexa-Amylose) · Cavamax W6 · Cavamax W 6 · Cyclohexapentylose · Cyclomaltohexose · alpha-cyclo Dextrin · Oristar acd · Ringdex-a · alpha- Cyclodextrin · alpha-Cycloamylose · gums · α-Cyclodextrin
What it does: Used in food as a thickener, adjuvant, carrier, stabilizer.
Thickener, adjuvant, carrier, stabilizer
Is it a concern?: Moderate concern: no hazard classifications on record.

Why it's flagged

EPA CPDat observed this chemical in 2 composition records across product categories including unclassified products.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Alfadex appears in these published regulatory listings.

Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Industrial

USFDAinactive ingredient database2 entries — 2 administration routes
- Route: INTRACAVERNOUS; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Maximum daily exposure: 2 mgSource →
- Route: INTRACAVITARY; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Potency: 1.29 mgSource →
EUEFSAEFSA opinionOpinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission related to the safety of alpha-cyclodextrin (EFSA NDA)
- Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission related to the safety of alpha-cyclodextrin (EFSA NDA)Source →
GLOBALJECFANOT SPECIFIEDJECFA evaluation lists ADI NOT SPECIFIED. Functional class: thickener, adjuvant, carrier, stabilizer.
- JECFA evaluation lists ADI NOT SPECIFIED. Functional class: thickener, adjuvant, carrier, stabilizer.Source →
GLOBALJECFAEvaluatedJECFA evaluation record.
- JECFA evaluation record.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 2 composition records across product categories including unclassified products.
- EPA CPDat observed this chemical in 2 composition records across product categories including unclassified products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

JECFA
Joint FAO/WHO Expert Committee on Food Additives
- JECFA evaluation lists ADI NOT SPECIFIED. Functional class: thickener, adjuvant, carrier, stabilizer.
  Year not recorded · GLOBAL JECFA listing · Read the source →
- JECFA evaluation record.
  Year not recorded · GLOBAL JECFA listing · Read the source →
EFSA
European Food Safety Authority
- Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission related to the safety of alpha-cyclodextrin (EFSA NDA)
  2007 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Alfadex yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated January 7, 2008
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
WHO JECFA Database
regulatory · updated 2026-10-04
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (2)

Openfda substance

microbiopharm.com

Read →

Openfda substance

cyclodextrin.org

Read →

Allergen profile

Canonical allergen markers detected on this ingredient. Each row is derived from the ingredient’s name or synonyms matching a known allergen class — useful when scanning a label for a specific allergy context.

GlutenContains · Oral (ingested)
Source: chemindex_name_match

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Alfadex in a product composition. These are source records, not Greenveil catalog products.

Source records

Named organisations

Typical roles

Thickener, adjuvant, carrier, stabilizer

See products using Alfadex →

Catalog

Found in these products

Their ingredient lists include Alfadex; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 253 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Alfadex in the catalog.