What does Sodium phosphate, monobasic, anhydrous do?

Used in food as an acidity regulator, sequestrant.

Is Sodium phosphate, monobasic, anhydrous safe?

Moderate concern: no hazard classifications on record.

beauty
cleaning
food
industrial

Sodium phosphate, monobasic, anhydrous

CAS 7558-80-7 · 40/100 · High conf.

Also registered as 3 other CAS numbers

1333-80-8 · 89140-32-9 · 943540-07-6

Sodium phosphate, monobasic, anhydrous chemical structure

Concern score

40/100Moderate concern based on regulatory listings.

High confidence

Sodium phosphate, monobasic, anhydrous in plain language

What it is: Also known as Monobasic sodium phosphate · Sodium phosphate monobasic · Monobasic anhydrous sodium phosphate · Cid 24204 · Monosodium monophosphate · Monosodium phosphate
Show all 25 names
Sodium acid phosphate · Sodium dihydrogen phosphate · Anhydrous monosodium phosphate · Phosphoric acid, monosodium salt, anhydrous · Anhydrous sodium biphosphate · Anhydrous sodium dihydrogen phosphate · Sodium orthophosphate monobasic · Sodium phosphate monobasic (anhydrate) · Sodium primary phosphate · Dihydrogen monosodium phosphate · Dihydrogen sodium phosphate · Dihydrogenoorthophosphate de sodium · E-339(I) · Ins NO.339(I) · INS-339(I) · Monosodium dihydrogen monophosphate · Monosodium dihydrogen orthophosphate · monosodium salt Phosphoric acid · dihidrogenoortofosfato de sodio
What it does: Used in food as an acidity regulator, sequestrant.
Acidity regulator, sequestrant
Emulsifier
Humectant
pH adjuster
Fragrance
Flavouring
Is it a concern?: Moderate concern: no hazard classifications on record.

Why it's flagged

EPA CPDat observed this chemical in 312 composition records across product categories including Construction and building materials, Laboratory supplies, Specialty occupational products.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Sodium phosphate, monobasic, anhydrous appears in these published regulatory listings.

In marketed US drugs
Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Pharma
Food
Industrial

USFDAinactive ingredient database41 entries — 16 administration routes
- Route: BUCCAL; Dosage form: FILM, SOLUBLE; Potency: 0.03 mgSource →
- Route: INTRA-ARTICULAR; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 13 mgSource →
- Route: INTRALESIONAL; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 10 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION; Maximum daily exposure: 13 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION, POWDER, FOR SOLUTION; Potency: 18.81 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Maximum daily exposure: 161 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION, SOLUTION; Potency: 0.62 %w/vSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 13 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION, SUSPENSION, EXTENDED RELEASE; Maximum daily exposure: 8 mgSource →
- Route: INTRAOCULAR; Dosage form: INSERT; Potency: 0.01 mgSource →
- Route: INTRASYNOVIAL; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 10 mgSource →
- Route: INTRAVASCULAR; Dosage form: INJECTION; Potency: 0.01 %w/vSource →
- Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 12.8 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, FOR SOLUTION; Potency: 18.81 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Maximum daily exposure: 161 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Potency: 0.62 %w/vSource →
- Route: INTRAVENOUS; Dosage form: SOLUTION; Potency: 40 mgSource →
- Route: INTRAVESICAL; Dosage form: SOLUTION; Potency: 0.12 mgSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION; Potency: 0.78 %w/vSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION/ DROPS; Potency: 0.46 %w/vSource →
- Route: OPHTHALMIC; Dosage form: SUSPENSION; Potency: 0.65 %w/wSource →
- Route: OPHTHALMIC; Dosage form: SUSPENSION/ DROPS; Potency: 0.44 %w/wSource →
- Route: ORAL; Dosage form: SOLUTION; Maximum daily exposure: 120 mgSource →
- Route: ORAL; Dosage form: SUSPENSION; Maximum daily exposure: 65 mgSource →
- Route: ORAL; Dosage form: SYRUP; Potency: 0.7 mg/1mlSource →
- Route: ORAL; Dosage form: TABLET; Potency: 4.18 mgSource →
- Route: ORAL; Dosage form: TABLET, DELAYED RELEASE; Potency: 23.4 mgSource →
- Route: ORAL; Dosage form: TABLET, EXTENDED RELEASE; Maximum daily exposure: 62 mgSource →
- Route: SOFT TISSUE; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 13 mgSource →
- Route: SUBCUTANEOUS; Dosage form: INJECTION; Potency: 33.1 mgSource →
- Route: SUBCUTANEOUS; Dosage form: INJECTION, POWDER, FOR SOLUTION; Potency: 0.2 mgSource →
- Route: SUBCUTANEOUS; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Potency: 1.1 mgSource →
- Route: TOPICAL; Dosage form: CREAM; Potency: 1 %w/wSource →
- Route: TOPICAL; Dosage form: GEL; Maximum daily exposure: 6 mgSource →
- Route: TOPICAL; Dosage form: LOTION; Potency: 0.2 %w/wSource →
- Route: TOPICAL; Dosage form: SHAMPOO, SUSPENSION; Potency: 1 %w/vSource →
- Route: TOPICAL; Dosage form: SOLUTION; Potency: 0.47 %w/vSource →
- Route: VAGINAL; Dosage form: CREAM; Potency: ADJ PHSource →
- Route: AURICULAR (OTIC); Dosage form: DROPS; Potency: 1.1 %w/wSource →
- Route: AURICULAR (OTIC); Dosage form: SOLUTION; Potency: 0.13 %w/wSource →
- + 1 more entries not shown
GLOBALJECFAEvaluated2 entries
- JECFA evaluation record.Source →
- JECFA evaluation record. Functional class: acidity regulator, sequestrant.Source →
EUEFSAEFSA opinionScientific Opinion on the safety evaluation of the active substances, iron, polyethyleneglycol, disodium pyrophosphate, monosodium phosphate and sodium chloride for use in food contact materials (EFSA CEF)
- Scientific Opinion on the safety evaluation of the active substances, iron, polyethyleneglycol, disodium pyrophosphate, monosodium phosphate and sodium chloride for use in food contact materials (EFSA CEF)Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 312 composition records across product categories including Construction and building materials, Laboratory supplies, Specialty occupational products. EPA CPDat classifies this chemical for functional uses including pH regulating agent, Pharmaceutical, Fragrance.
- EPA CPDat observed this chemical in 312 composition records across product categories including Construction and building materials, Laboratory supplies, Specialty occupational products. EPA CPDat classifies this chemical for functional uses including pH regulating agent, Pharmaceutical, Fragrance.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 2 active drug products and 2 total products.
- FDA NDC lists this ingredient in 2 active drug products and 2 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

JECFA
Joint FAO/WHO Expert Committee on Food Additives
- JECFA evaluation record.
  Year not recorded · GLOBAL JECFA listing · Read the source →
- JECFA evaluation record. Functional class: acidity regulator, sequestrant.
  Year not recorded · GLOBAL JECFA listing · Read the source →
EFSA
European Food Safety Authority
- Scientific Opinion on the safety evaluation of the active substances, iron, polyethyleneglycol, disodium pyrophosphate, monosodium phosphate and sodium chloride for use in food contact materials (EFSA CEF)
  2013 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Sodium phosphate, monobasic, anhydrous yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated September 2013
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA National Drug Code Directory
regulatory · updated 2026-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
WHO JECFA Database
regulatory · updated 2026-10-04
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (1)

Openfda substance

codexalimentarius.net

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Sodium phosphate, monobasic, anhydrous in a product composition. These are source records, not Greenveil catalog products.

Source records

312

Named organisations

Construction and building materialsLaboratory suppliesSpecialty occupational productsCleaning products and household carePesticidesMedical/dental

Typical roles

Acidity regulator, sequestrantEmulsifierHumectantpH adjusterFragranceFlavouring

See products using Sodium phosphate, monobasic, anhydrous →

Catalog

Found in these products

Their ingredient lists include Sodium phosphate, monobasic, anhydrous; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 24 →Find products without it →