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Tocopherol

CAS 1406-66-2 · 40/100 · High conf.

Also registered as 4 other CAS numbers

7616-22-0 · 73980-80-0 · 146814-15-5 · 188763-17-9

Tocopherol chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Tocopherol in plain language

What it is

Also known as Mixed rrr-tocopherols concentrate · Tocopherols mixed · D-gamma-Tocopherol · Tocopherols · Tocopherols (mixed) · E-306

Show all 37 names

Mixed tocopherols · 0.1% mixed tocopherols (added as a stabilizer) · Antioxidans E-Hevert · BatanaOil · Covi-ox t 50 c · Covi-ox t 70 c · Dal E · E Mulsin · E Vicotrat · Golden Tocopherol 70 · Grindox 497 · Irganox E 217DF · Lasar · Mixed tocopherols 95 · Methyltocols · Micorvit E · Oristar mixed tocopherols · Tocoferoles · UnoVit · VitaE · VitaPlus E · Vitamin E Dragees · Vitamin E EVI MIRALE · Vitamin E mp · Mowivit Vitamin E · Togasan Vitamin E · Vitagutt Vitamin E · Vitamin Emp · VitaminE EVIMIRALE · tocopherol (non gmo vitamin e soy) · tocopherol (vitamin e)

What it does

Used in consumer products as an antioxidant, a humectant and a fragrance ingredient.

  • Antioxidant
  • Humectant
  • Fragrance
  • Flavouring
  • Conditioner
  • Deodorant
Is it a concern?
Moderate concern: no hazard classifications on record.

Why it's flagged

EPA CPDat observed this chemical in 13741 composition records across product categories including Personal care, Construction, Cleaning products and household care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Tocopherol appears in these published regulatory listings.

  • In marketed US drugs
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • Industrial
  • USFDAinactive ingredient database5 entries — 3 administration routes
    • Route: TOPICAL; Dosage form: CREAM; Potency: NASource →
    • Route: ORAL; Dosage form: TABLET; Potency: 0.08 mgSource →
    • Route: ORAL; Dosage form: CAPSULE, COATED; Potency: 0.25 mgSource →
    • Route: ORAL; Dosage form: CAPSULE; Potency: NASource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, EMULSION; Potency: 0.02 %w/vSource →
  • EUEFSAEFSA opinion2 entries
    • Scientific Opinion on the re-evaluation of tocopherol-rich extract (E 306), alpha-tocopherol (E 307), gamma-tocopherol (E 308) and delta-tocopherol (E 309) as food additives (EFSA ANS)Source →
    • Opinion on mixed tocopherols, tocotrienol tocopherol and tocotrienols as sources for vitamin E added as a nutritional substance in food supplements - Scientific Opinion of the Panel on Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)Source →
  • EUEFSAEFSA statementInability to assess the safety of beta-, gamma- and delta- tocopherol and alpha-, beta-, gamma-, delta- and desmethyl-tocotrienol added for nutritional purposes as sources of beta-, gamma- and deltatocopherol and alpha-, beta-, gamma-, delta- and desmethyltocotrienol in food supplements and the bioavailability of beta-, gamma-, delta- tocopherol and alpha-, beta-, gamma-, delta- and desmethyl-tocotrienol from the different sources, based on the supporting dossiers (EFSA ANS)
    • Inability to assess the safety of beta-, gamma- and delta- tocopherol and alpha-, beta-, gamma-, delta- and desmethyl-tocotrienol added for nutritional purposes as sources of beta-, gamma- and deltatocopherol and alpha-, beta-, gamma-, delta- and desmethyltocotrienol in food supplements and the bioavailability of beta-, gamma-, delta- tocopherol and alpha-, beta-, gamma-, delta- and desmethyl-tocotrienol from the different sources, based on the supporting dossiers (EFSA ANS)Source →
  • GLOBALJECFAEvaluatedJECFA evaluation record.
  • USEPAcommercial use observedEPA CPDat observed this chemical in 13741 composition records across product categories including Personal care, Construction, Cleaning products and household care. EPA CPDat classifies this chemical for functional uses including Antioxidant, Pharmaceutical, Deodorizer.
    • EPA CPDat observed this chemical in 13741 composition records across product categories including Personal care, Construction, Cleaning products and household care. EPA CPDat classifies this chemical for functional uses including Antioxidant, Pharmaceutical, Deodorizer.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 25 active drug products and 32 total products.
    • FDA NDC lists this ingredient in 25 active drug products and 32 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as mixture.
    • openFDA substance registry classifies this ingredient as mixture.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

  • EFSA

    European Food Safety Authority

    • Scientific Opinion on the re-evaluation of tocopherol-rich extract (E 306), alpha-tocopherol (E 307), gamma-tocopherol (E 308) and delta-tocopherol (E 309) as food additives (EFSA ANS)

      2015 · EU EFSA listing · Read the source →

    • Opinion on mixed tocopherols, tocotrienol tocopherol and tocotrienols as sources for vitamin E added as a nutritional substance in food supplements - Scientific Opinion of the Panel on Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)

      2008 · EU EFSA listing · Read the source →

    • Inability to assess the safety of beta-, gamma- and delta- tocopherol and alpha-, beta-, gamma-, delta- and desmethyl-tocotrienol added for nutritional purposes as sources of beta-, gamma- and deltatocopherol and alpha-, beta-, gamma-, delta- and desmethyltocotrienol in food supplements and the bioavailability of beta-, gamma-, delta- tocopherol and alpha-, beta-, gamma-, delta- and desmethyl-tocotrienol from the different sources, based on the supporting dossiers (EFSA ANS)

      2009 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Tocopherol yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated september 25, 2019

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2028-03-09

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • WHO JECFA Database

    regulatory · updated 2026-10-04

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

sciencedirect.com

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Tocopherol in a product composition. These are source records, not Greenveil catalog products.

Source records

13,741

Named organisations

6

Personal careConstructionCleaning products and household careFood and drugMedical/dentalBatteries

Typical roles

AntioxidantHumectantFragranceFlavouringConditionerDeodorant
See products using Tocopherol →

Catalog

Found in these products

Their ingredient lists include Tocopherol; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Tocopherol in the catalog.