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Natamycin

CAS 141-35-5 · 40/100 · High conf.

Also registered as 6 other CAS numbers

306-36-5 · 1383-95-5 · 1406-71-9 · 81612-01-3 · 223558-57-4 · 7681-93-8

Natamycin chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Natamycin in plain language

What it is

Also known as Pimaricin · Pimaracin · Tennecetin · Antibiotic A-5283 · Cl 12,625 · CL-12625

Show all 22 names

Delvocid · Delvolan · E-235 · Ins NO.235 · INS-235 · Mycophyt · Myprozine · Natacyn · Natamycinum · Pimafucin · Pimaricine · Pimarizin · Synogil · natamicina · natamycine · δ-Natamycin

What it does

Used in cosmetics as a preservative and an antimicrobial.

  • Preservative
  • Antimicrobial
Is it a concern?
Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 113 composition records across product categories including Personal care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Natamycin appears in these published regulatory listings.

  • In marketed US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • EUEFSAEFSA opinionScientific Opinion on the use of natamycin (E 235) as a food additive (EFSA ANS)
    • Scientific Opinion on the use of natamycin (E 235) as a food additive (EFSA ANS)Source →
  • GLOBALJECFA0-0.3 mg/kg bw (1976)JECFA evaluation lists ADI 0-0.3 mg/kg bw (1976). Functional class: preservative.
    • JECFA evaluation lists ADI 0-0.3 mg/kg bw (1976). Functional class: preservative.Source →
  • GLOBALJECFAEvaluatedJECFA evaluation record.
  • USEPAcommercial use observedEPA CPDat observed this chemical in 113 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Biocide, Preservative.
    • EPA CPDat observed this chemical in 113 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Biocide, Preservative.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 2 active drug products and 2 total products.
    • FDA NDC lists this ingredient in 2 active drug products and 2 total products.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Scientific Opinion on the use of natamycin (E 235) as a food additive (EFSA ANS)

      2009 · EU EFSA listing · Read the source →

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    • JECFA evaluation lists ADI 0-0.3 mg/kg bw (1976). Functional class: preservative.

      Year not recorded · GLOBAL JECFA listing · Read the source →

    • JECFA evaluation record.

      Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Natamycin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated March 2015

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2026-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • WHO JECFA Database

    regulatory · updated 2026-10-04

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (3)
Openfda substance

nelsonjameson.com

Read →
Openfda substance

codexalimentarius.net

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Natamycin in a product composition. These are source records, not Greenveil catalog products.

Source records

113

Named organisations

6

Personal care

Typical roles

PreservativeAntimicrobial
See products using Natamycin →

Catalog

Found in these products

Their ingredient lists include Natamycin; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 32 →Find products without it →